Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

25 questions · 27 findings · 11 reviews

No studies found 2 · 7.4%GRADE not reported 0 · 0%Very low 18 · 66.7%Low 4 · 14.8%Moderate 2 · 7.4%High 1 · 3.7%

More intensive vs less intensive insulin therapy

Transplant or graft survival · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes transplant or graft survival compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Delayed graft function · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes delayed graft function Time frame: 1 to 3 years compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Death: unknown time frame · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes death (any cause) Time frame: 1 to 5 years compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

Less intensive vs more intensive follow‐up after primary cancer treatment

Depression · adult cancer survivors from the following cancer sites: breast, colorectal, head‐and‐neck, Hodgkin lymphoma, melanoma, non‐small cell lung…

The review found no eligible studies for this question.

1 finding from 1 review

Less intensive vs more intensive follow‐up after primary cancer treatment

Overall survival · adult cancer survivors from the following cancer sites: breast, colorectal, head‐and‐neck, Hodgkin lymphoma, melanoma, non‐small cell lung…

Less intensive showed no clear difference in overall survival compared with more intensive follow‐up after primary cancer treatment (low certainty).

1 finding from 1 review

Less intensive vs more intensive follow‐up after primary cancer treatment

Time to detection of recurrence · adult cancer survivors from the following cancer sites: breast, colorectal, head‐and‐neck, Hodgkin lymphoma, melanoma, non‐small cell lung…

Less intensive probably leads to lower time to detection of recurrence compared with more intensive follow‐up after primary cancer treatment (moderate certainty).

1 finding from 1 review

Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention

Change in visual loss associated with PSR: visual loss is defined by the deterioration of visual acuity of 3 lines or more with the Snellen chart · type 1 or type 2 diabetics

It is very uncertain whether blood pressure intervention/intensive blood pressure intervention changes visual acuity (loss of 3 lines or more) by 5 years compared with placebo/standard blood pressure intervention (very low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Significant maternal morbidity one or more of the following: significant postpartum haemorrhage requiring blood transfusion; maternal admission to intensive care unit; uterine rupture; hysterectomy · pregnant women with a term suspected compromised baby

Planned early delivery showed no clear difference in significant maternal morbidity one or more of the following:… compared with expectant management (low certainty).

1 finding from 1 review

Perioperative alcohol cessation intervention vs treatment

Postoperative complications after perioperative intervention (e.g. wound‐related complications, secondary surgery, cardiopulmonary complications, admission to intensive care) defined by need for treatment · adult surgical patients consuming 3 or more units of alcohol per day

Perioperative alcohol cessation intervention probably leads to lower postoperative complications after perioperative intervention (e.g.… compared with treatment (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Mortality and morbidity prior to discharge (Neonatal intensive care admissions) · Women with meconium‐stained amniotic fluid in labour, gestational age more than 24 weeks

Antibiotic showed no clear difference in mortality and morbidity prior to discharge (Neonatal intensive care… compared with placebo (low certainty).

1 finding from 1 review