Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

29 questions · 29 findings · 11 reviews · Neonatal · Headline outcomes only

No studies found 12 · 41.4%GRADE not reported 1 · 3.4%Very low 9 · 31%Low 5 · 17.2%Moderate 0 · 0%High 2 · 6.9%

Late (seven days or more following birth) higher vs lower sodium intake

Mortality Mortality at latest · preterm or low birth weight infants

It is very uncertain whether late (seven days or more following birth) higher changes mortality (latest time reported up to hospital discharge) compared with lower sodium intake (very low certainty).

1 finding from 1 review

Intervention not reported

Episodes of bradycardia, defined as a fall in heart rate of more than 30% below the baseline or less than 100 beats per minute for 10 seconds or longer, occurring during the procedure · Procedural pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Caffeine vs other methylxanthines

c) Developmental delay more than two SDs below population mean on a standardized test of development: cognitive delay № of participants: 79(1 RCT) · preterm infants

It is very uncertain whether caffeine changes c) Developmental delay more than two SDs below population mean on a… compared with other methylxanthines (very low certainty).

1 finding from 1 review

Caffeine vs other methylxanthines

c) Developmental delay more than two SDs below population mean on a standardized test of development: language delay № of participants: 79(1 RCT) · preterm infants

It is very uncertain whether caffeine changes c) Developmental delay more than two SDs below population mean on a… compared with other methylxanthines (very low certainty).

1 finding from 1 review

Caffeine vs other methylxanthines

c) Developmental delay more than two SDs below population mean on a standardized test of development: motor delay № of participants: 79(1 RCT) · preterm infants

It is very uncertain whether caffeine changes c) Developmental delay more than two SDs below population mean on a… compared with other methylxanthines (very low certainty).

1 finding from 1 review