Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

163 questions · 167 findings · 14 reviews

No studies found 23 · 13.8%GRADE not reported 8 · 4.8%Very low 44 · 26.3%Low 65 · 38.9%Moderate 27 · 16.2%High 0 · 0%

Oral misoprostol vs vaginal misoprostol

Uterine hyperstimulation with fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower uterine hyperstimulation with fetal heart rate changes compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Oral misoprostol vs vaginal misoprostol

Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower uterine hyperstimulation without fetal heart rate changes compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Oral misoprostol vs vaginal misoprostol

Admission to neonatal intensive care unit · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in admission to neonatal intensive care unit compared with vaginal misoprostol (moderate certainty).

1 finding from 1 review

Advance misoprostol distribution/provision to pregnant women for postpartum self‐administration vs usual care

Women not using/receiving misoprostol at birth · women in the third stage of labour

It is very uncertain whether advance misoprostol distribution/provision to pregnant women for… changes women not using/receiving misoprostol at birth compared with usual (or standard) care (very low certainty).

1 finding from 1 review

Advance misoprostol distribution/provision to pregnant women for postpartum self‐administration vs usual care

Inappropriate use (or misuse) of misoprostol · women in the third stage of labour

It is very uncertain whether advance misoprostol distribution/provision to pregnant women for… changes inappropriate use (or misuse) of misoprostol compared with usual (or standard) care (very low certainty).

1 finding from 1 review

Oral misoprostol vs vaginal misoprostol

Failure to achieve complete abortion · women undergoing first trimester abortion

Oral misoprostol probably leads to higher failure to achieve complete abortion compared with vaginal misoprostol (moderate certainty).

2 findings from 1 review

Misoprostol vs surgery

Unplanned surgical intervention · incomplete miscarriage

Misoprostol may leads to higher unplanned surgical intervention compared with surgery (low certainty).

1 finding from 1 review

Misoprostol vs surgery

Women's views/acceptability of method · incomplete miscarriage

Misoprostol showed no clear difference in women's views/acceptability of method compared with surgery (moderate certainty).

1 finding from 1 review