Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

75 questions · 75 findings · 8 reviews · Headline outcomes only

No studies found 23 · 30.7%GRADE not reported 1 · 1.3%Very low 16 · 21.3%Low 24 · 32%Moderate 11 · 14.7%High 0 · 0%

Mannitol vs phenolphthalein or rhubarb soda

Global or clinical change in constipation as defined by the study a) Still constipated (no defecation) at 24 hours · antipsychotic‐related constipation

It is very uncertain whether mannitol changes global or clinical change in constipation as defined by the study a)… compared with phenolphthalein or rhubarb soda (very low certainty).

1 finding from 1 review