Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

247 questions · 258 findings · 21 reviews

No studies found 84 · 32.6%GRADE not reported 12 · 4.7%Very low 78 · 30.2%Low 56 · 21.7%Moderate 22 · 8.5%High 6 · 2.3%

Magnesium sulfate vs ipratropium

Proportion of people with hospital admissions (from the emergency room) · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether magnesium sulfate changes proportion of people with hospital admissions (from the emergency… compared with standard care (ipratropium bromide) (very low certainty).

1 finding from 1 review

Magnesium sulfate vs ipratropium

Endotracheal intubation To discharge · acute exacerbations of chronic obstructive pulmonary disease

It is very uncertain whether magnesium sulfate changes proportion of people requiring endotracheal intubation compared with standard care (ipratropium bromide) (very low certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Death (fetal, neonatal, or later (up to 2 years' corrected age))** · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death (fetal, neonatal, or later (up to 2 years' corrected age))** compared with placebo (outcomes (moderate certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Death or cerebral palsy · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death or cerebral palsy (up to school age)** compared with placebo (outcomes (low certainty).

2 findings from 1 review

Magnesium sulphate vs placebo (outcomes

Major neurodevelopmental disability at childhood · women at risk of preterm birth (< 34 weeks' gestation)

It is very uncertain whether magnesium sulphate changes major neurodevelopmental disability (school age)** compared with placebo (outcomes (very low certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Death or major neurodevelopmental disability · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death or major neurodevelopmental disability (up to school age)** compared with placebo (outcomes (low certainty).

2 findings from 1 review

Magnesium sulphate vs placebo (outcomes

Severe maternal outcome potentially related to treatment (death, respiratory arrest, or cardiac arrest)** · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in severe maternal outcome potentially related to treatment (death,… compared with placebo (outcomes (low certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Cerebral palsy · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate leads to lower cerebral palsy (up to 2 years' corrected age)** compared with placebo (outcomes (high certainty).

2 findings from 1 review