Development of post-radiotherapy dental complications (caries, fractured teeth, periapical infection, periodontal disease, osteoradionecrosis) · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Development of post-radiotherapy dental complications (caries, fractured teeth, periapical infection, periodontal disease, osteoradionecrosis) · Patients diagnosed with head and neck cancer planned to undergo any type of radiotherapy (external beam, intensity modulated,…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Locoregional control · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Concomitant (concurrent) chemoradiotherapy led to lower locoregional control, concurrent chemoradiotherapy (platinum +… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.
1 finding from 1 review
RR 0.75 [0.61, 0.93]
3 studies
GRADE not reported
Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Concomitant (concurrent) chemoradiotherapy led to lower disease-free survival, concurrent chemoradiotherapy vs radiotherapy… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.
1 finding from 1 review
HR 0.74 [0.67, 0.80]
13 studies
GRADE not reported
Overall survival, adjuvant concomitant chemoradiotherapy vs post-surgery radiotherapy alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Concomitant (concurrent) chemoradiotherapy probably leads to lower overall survival, concurrent chemoradiotherapy vs radiotherapy alone… compared with radiotherapy alone (non-resectable tumours) (moderate certainty).
1 finding from 1 review
Overall survival, post-surgery chemotherapy vs surgery alone (no radiotherapy) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Surgery +/- radiotherapy + (adjuvant) chemotherapy showed no clear difference in overall survival, adjuvant chemotherapy vs observation alone… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy… (moderate certainty).
1 finding from 1 review
Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Surgery +/- radiotherapy + (adjuvant) chemotherapy led to lower disease-free survival, adjuvant concurrent chemoradiation vs… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy…; GRADE not reported.
1 finding from 1 review
HR 0.84 [0.72, 0.97]
4 studies
GRADE not reported
Overall survival, adjuvant concomitant chemoradiotherapy vs post-surgery radiotherapy alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Surgery +/- radiotherapy + (adjuvant) chemotherapy probably leads to lower overall survival, adjuvant concurrent chemoradiation vs adjuvant… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy… (moderate certainty).
1 finding from 1 review
Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
1 finding from 1 review
Induction cisplatin+5-FU+docetaxel vs cisplatin+5-FU: disease-free survival HR 0.72 (95% CI 0.57 to 0.91, P = 0.006; Vermorken 2007). Prior to concurrent chemoradiation: Posner 2007 HR 0.71 (0.56 to 0.90, P = 0.005).…
2 studies
GRADE not reported
Overall survival (total mortality), chemotherapy regimen A vs regimen B · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
1 finding from 1 review
Locoregional control · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
1 finding from 1 review
Toxicity / adverse effects (harms) of chemotherapy · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
1 finding from 1 review
Overall survival, induction platinum + 5-fluorouracil prior to radiotherapy vs radiotherapy alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction platinum + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone (moderate certainty).
1 finding from 1 review
Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Induction chemotherapy plus locoregional treatment (radiotherapy… led to lower disease-free survival, induction platinum + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone; GRADE not reported.
1 finding from 1 review
Preimplantation complications · Patients who have had radiotherapy and who have missing teeth that require replacement with osseointegrated dental implants
Hyperbaric oxygen (HBO) therapy led to lower preimplantation complications compared with no HBO therapy; GRADE not reported.
1 finding from 1 review
Analysis 1.1 (Dichotomous outcomes: Preimplantation complications): Risk Ratio (M-H, Fixed, 95% CI), totals not selected; not estimable (no events in either arm).
1 study · 24 participants
GRADE not reported
Prosthetic failure (2 years) · Patients who have had radiotherapy and who have missing teeth that require replacement with osseointegrated dental implants
It is very uncertain whether hyperbaric oxygen (HBO) therapy changes prosthetic failure compared with no HBO therapy (very low certainty).
1 finding from 1 review
Marginal bone level change · Patients who have had radiotherapy and who have missing teeth that require replacement with osseointegrated dental implants
1 finding from 1 review
Overall denture satisfaction (0-10 scale) · Patients who have had radiotherapy and who have missing teeth that require replacement with osseointegrated dental implants
Hyperbaric oxygen (HBO) therapy showed no clear difference in patient satisfaction (overall denture satisfaction) compared with no HBO therapy; GRADE not reported.
1 finding from 1 review
Analysis 1.2 (Overall denture satisfaction): Mean Difference (IV, Fixed, 95% CI), totals not selected (value not displayed).
1 study · 17 participants
GRADE not reported
Cost‐effectiveness · Patients who have had radiotherapy and who have missing teeth that require replacement with osseointegrated dental implants
The review found no eligible studies for this question.
1 finding from 1 review
Implant failure · Patients who have had radiotherapy and who have missing teeth that require replacement with osseointegrated dental implants
Hyperbaric oxygen (HBO) therapy showed no clear difference in implant failure compared with no HBO therapy; GRADE not reported.
1 finding from 1 review