Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Chemotherapy vs chemotherapy alone

Overall survival (taxane‐containing doublet therapy vs taxane monotherapy) · advanced gastric adenocarcinoma

Chemotherapy showed no clear difference in overall survival (taxane‐containing doublet therapy vs taxane… compared with chemotherapy (low certainty).

1 finding from 1 review

Chemotherapy vs chemotherapy alone

Progression‐free survival (PSF) · advanced gastric adenocarcinoma

Chemotherapy showed no clear difference in progression‐free survival (non‐taxane monotherapy vs taxane… compared with chemotherapy (low certainty).

3 findings from 1 review

Chemotherapy vs chemotherapy alone

Tumour response · advanced gastric adenocarcinoma

Chemotherapy showed no clear difference in tumour response rate (non‐taxane monotherapy vs taxane monotherapy) compared with chemotherapy (low certainty).

2 findings from 1 review

Chemotherapy vs chemotherapy alone

Tumour response rate (taxane‐containing doublet therapy vs taxane monotherapy) · advanced gastric adenocarcinoma

It is very uncertain whether chemotherapy changes tumour response rate (taxane‐containing doublet therapy vs taxane… compared with chemotherapy (very low certainty).

1 finding from 1 review

Hypnotherapy vs behavioural treatments or no treatment

Smoking cessation · people who smoke

Hypnotherapy showed no clear difference in hypnotherapy versus attention‐matched behavioural treatments Smoking… compared with behavioural treatments or no treatment (low certainty).

4 findings from 1 review
Show 1 more finding

Aromatherapy vs placebo

Adverse events (common reactions to aromatherapy include skin rashes, dyspnoea, headache, cardiac arrhythmias, hypotension, hypertension or dizziness) · adults and children having any type of surgical procedure under general anaesthesia, regional anaesthesia or sedation, as hospital…

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Light therapy vs no light therapy

Incidence of SAD (SIGH‐SAD score ≥ 20) ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether light therapy changes incidence of SAD (SIGH‐SAD score ≥ 20) ( compared with no light therapy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Light therapy vs no light therapy

Incidence of severe SAD (SIGH‐SAD‐SR (≥ 40)) ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether light therapy changes incidence of severe SAD (SIGH‐SAD‐SR (≥ 40)) ( compared with no light therapy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Light therapy vs no light therapy

Overall discontinuation ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether light therapy changes overall discontinuation ( compared with no light therapy (very low certainty).

1 finding from 1 review

Antibiotics vs placebo compared

Adverse effects of antibiotics · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze

Antibiotic therapy showed no clear difference in treatment harms (adverse events or side effects associated with… compared with placebo compared to placebo (low certainty).

1 finding from 1 review

Infrared light therapy vs no light therapy

Incidence of SAD (SIGH‐SAD score ≥ 20) ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether infrared light therapy changes incidence of SAD (SIGH‐SAD score ≥ 20) ( compared with no light therapy (very low certainty).

1 finding from 1 review

Infrared light therapy vs no light therapy

Incidence of severe SAD (SIGH‐SAD‐SR (≥ 40)) ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether infrared light therapy changes incidence of severe SAD (SIGH‐SAD‐SR (≥ 40)) ( compared with no light therapy (very low certainty).

1 finding from 1 review

Infrared light therapy vs no light therapy

Overall discontinuation ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether infrared light therapy changes overall discontinuation ( compared with no light therapy (very low certainty).

1 finding from 1 review

Bright white light therapy vs no light therapy

Incidence of SAD (SIGH‐SAD score ≥ 20) ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether bright white light therapy changes incidence of SAD (SIGH‐SAD score ≥ 20) ( compared with no light therapy (very low certainty).

1 finding from 1 review

Bright white light therapy vs infrared light therapy

Incidence of SAD (SIGH‐SAD score ≥ 20) ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether bright white light therapy changes incidence of SAD (SIGH‐SAD score ≥ 20) ( compared with infrared light therapy (very low certainty).

1 finding from 1 review

Bright white light therapy vs infrared light therapy

Incidence of severe SAD (SIGH‐SAD‐SR (≥ 40)) ( · All participants were known SAD patients who had been successfully treated with conventional light therapy in previous winters

It is very uncertain whether bright white light therapy changes incidence of severe SAD (SIGH‐SAD‐SR (≥ 40)) ( compared with infrared light therapy (very low certainty).

1 finding from 1 review