Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

256 questions · 282 findings · 27 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 38 · 13.5%GRADE not reported 32 · 11.3%Very low 62 · 22%Low 64 · 22.7%Moderate 62 · 22%High 24 · 8.5%

Lifestyle interventions vs placebo or usual care

Cardiovascular and metabolic event frequency (12 months) (Number of strokes, myocardial infarctions and hospitalisations for heart failure) · weight reduction in obesity to improve survival in women with endometrial cancer

Summary of findings table ‐ Lifestyle intervention showed no clear difference in cardiovascular and metabolic event frequency (6 months) compared with usual care compared to placebo (low certainty).

1 finding from 1 review

Exposure to any ovary‐stimulating drugs for subfertility vs untreated subfertile women and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to any ovary‐stimulating drugs for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to any ovary‐stimulating drugs for subfertility vs general population and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to any ovary‐stimulating drugs for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to clomiphene citrate for subfertility vs untreated subfertile women and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to clomiphene citrate for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to clomiphene citrate for subfertility vs general population and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to clomiphene citrate for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to gonadotropins for subfertility vs untreated subfertile women and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to gonadotropins for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to gonadotropins for subfertility vs general population and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to gonadotropins for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to clomiphene citrate and gonadotropins for subfertility vs untreated subfertile women and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to clomiphene citrate and gonadotropins for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to clomiphene citrate and gonadotropins for subfertility vs general population and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to clomiphene citrate and gonadotropins for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).

1 finding from 1 review

GnRH analogues vs untreated subfertile women and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to GnRH analogues for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).

1 finding from 1 review

Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy

Absence of nausea ( · people with chemotherapy‐induced nausea and vomiting

It is very uncertain whether cannabinoid plus other anti‐emetic agent changes absence of nausea ( compared with other anti‐emetic monotherapy (very low certainty).

1 finding from 1 review

Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy

Absence of vomiting ( · people with chemotherapy‐induced nausea and vomiting

Cannabinoid plus other anti‐emetic agent showed no clear difference in absence of vomiting ( compared with other anti‐emetic monotherapy (low certainty).

1 finding from 1 review

Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy

Absence of nausea and vomiting ( · people with chemotherapy‐induced nausea and vomiting

Cannabinoid plus other anti‐emetic agent showed no clear difference in absence of nausea and vomiting ( compared with other anti‐emetic monotherapy (low certainty).

1 finding from 1 review

Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy

Withdrawal for any reason (medium term: treatment duration from 5 to 8 weeks) · people with chemotherapy‐induced nausea and vomiting

Cannabinoid plus other anti‐emetic agent showed no clear difference in withdrawal any reason ( compared with other anti‐emetic monotherapy (low certainty).

1 finding from 1 review

Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy

Withdrawals due to adverse events · people with chemotherapy‐induced nausea and vomiting

It is very uncertain whether cannabinoid plus other anti‐emetic agent changes withdrawal due to adverse event ( compared with other anti‐emetic monotherapy (very low certainty).

1 finding from 1 review

Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy

Lack of efficacy withdrawal · people with chemotherapy‐induced nausea and vomiting

Cannabinoid plus other anti‐emetic agent showed no clear difference in withdrawal due to lack of efficacy ( compared with other anti‐emetic monotherapy (low certainty).

1 finding from 1 review

Dexrazoxane vs no cardioprotective intervention

Tumour response rate Defined as number of complete responses (i.e. disappearance of active Hodgkin lymphoma (gallium negative, ≥ 70% decrease in the sum of the products of the perpendicular diameters of measurable lesions, and negative bone marrow... · children with cancer receiving anthracyclines

Dexrazoxane showed no clear difference in tumour response rate Defined as number of complete responses (i.e.… compared with no cardioprotective intervention (low certainty).

1 finding from 1 review