Cochrane · systematic review · CD009464
Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy
Smith, LA, Azariah, F, Lavender, VTC, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
19
current version
GRADE rated
19
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 26.3%Low 12 · 63.2%Moderate 2 · 10.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Cannabinoids compared with placebo for chemotherapy‐induced nausea and vomiting
Population: people with chemotherapy‐induced nausea and vomiting
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Absence of nausea ( Cannabinoids vs placebo | RR 2 [0.2, 21] | 2 studies · 96 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Absence of vomiting ( Cannabinoids vs placebo | RR 5.7 [2.6, 12.6] | 3 studies · 168 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Absence of nausea and vomiting ( Cannabinoids vs placebo | RR 2.9 [1.8, 4.7] | 3 studies · 288 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Participant preference ( Cannabinoids vs placebo | RR 4.8 [1.7, 13] | 2 studies · 256 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Withdrawal any reason ( Cannabinoids vs placebo | RR 0.31 [0.01, 7] | 1 study · 33 participants | Very low Downgraded: imprecision |
Withdrawal due to adverse event ( Cannabinoids vs placebo | RR 6.9 [1.96, 24] | 2 studies · 276 participants | Very low Downgraded: imprecision |
Cannabinoids compared with other anti‐emetic agent for chemotherapy‐induced nausea and vomiting
Population: people with chemotherapy‐induced nausea and vomiting
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Absence of nausea ( Cannabinoids vs other anti‐emetic agent | RR 1.46 [0.67, 3.15] | 5 studies · 258 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Absence of vomiting ( Cannabinoids vs other anti‐emetic agent | RR 1.1 [0.86, 1.4] | 4 studies · 209 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Absence of nausea and vomiting ( Cannabinoids vs other anti‐emetic agent | RR 2 [0.74, 5.4] | 4 studies · 414 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Participant preference ( Cannabinoids vs other anti‐emetic agent | RR 2.8 [1.9, 4] | 9 studies · 799 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Withdrawal any reason ( Cannabinoids vs other anti‐emetic agent | RR 3.5 [1.4, 9] | 1 study · 42 participants | Low Downgraded: imprecision |
Withdrawal due to lack of efficacy ( Cannabinoids vs other anti‐emetic agent | RR 0.97 [0.04, 21] | 2 studies · 118 participants | Very low Downgraded: imprecision |
Withdrawal due to adverse event ( Cannabinoids vs other anti‐emetic agent | RR 3.2 [1.3, 8] | 6 studies · 740 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Cannabinoid plus other anti‐emetic agent compared with other anti‐emetic monotherapy for chemotherapy‐induced nausea and vomiting
Population: people with chemotherapy‐induced nausea and vomiting
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Absence of nausea ( Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy | RR 10 [0.61, 183] | 1 study · 37 participants | Very low Downgraded: imprecision |
Absence of vomiting ( Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy | RR 1.5 [0.69, 3.1] | 2 studies · 89 participants | Low Downgraded: imprecision |
Absence of nausea and vomiting ( Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy | RR 1.6 [0.68, 3.6] | 1 study · 37 participants | Low Downgraded: imprecision |
Withdrawal any reason ( Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy | RR 1.3 [0.41, 4.2] | 1 study · 41 participants | Low Downgraded: imprecision |
Withdrawal due to adverse event ( Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy | RR 7 [0.88, 55] | 2 studies · 105 participants | Very low Downgraded: imprecision |
Withdrawal due to lack of efficacy ( Cannabinoid plus other anti‐emetic agent vs other anti‐emetic monotherapy | RR 0.12 [0.01, 2] | 1 study · 41 participants | Low Downgraded: imprecision |