Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

237 questions · 238 findings · 41 reviews · Musculoskeletal · Headline outcomes only

No studies found 43 · 18.1%GRADE not reported 7 · 2.9%Very low 48 · 20.2%Low 89 · 37.4%Moderate 39 · 16.4%High 12 · 5%

Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension

Global assessment of treatment success · patients with adhesive capsulitis (frozen shoulder)

Combination of manual therapy and exercise following joint distension leads to higher global assessment of treatment success "Success, much improved,… compared with sham ultrasound following joint distension (high certainty).

1 finding from 1 review

Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension

Adverse events · patients with adhesive capsulitis (frozen shoulder)

Combination of manual therapy and exercise following joint distension leads to lower adverse events compared with sham ultrasound following joint distension (high certainty).

1 finding from 1 review

Autologous blood or PRP vs placebo at 3 months' follow‐up

Adverse events (pain and swelling at injection site and limitation of elbow movement following injection) · lateral elbow pain

Autologous blood or PRP showed no clear difference in adverse events (pain and swelling at injection site and limitation… compared with placebo at 3 months' follow‐up (low certainty).

1 finding from 1 review

Low‐dose colchicine vs placebo

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

Low‐dose colchicine may leads to higher participant global assessment of treatment success: proportion with… compared with placebo (low certainty).

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Global assessment of treatment success · acute gout

Low‐dose colchicine showed no clear difference in participant global assessment of treatment success: Completely… compared with NSAIDs (low certainty).

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Reduction of inflammation ‐ not measured · acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Function of target joint ‐ not measured · acute gout

The review found no eligible studies for this question.

1 finding from 1 review