Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

188 questions · 193 findings · 30 reviews · Schizophrenia

No studies found 54 · 28%GRADE not reported 23 · 11.9%Very low 50 · 25.9%Low 47 · 24.4%Moderate 15 · 7.8%High 4 · 2.1%

RISPERIDONE vs QUETIAPINE

Leaving the study early · people with both severe mental illness and substance misuse

RISPERIDONE showed no clear difference in leaving the study early: 1. any reason, long term (>12 months) compared with QUETIAPINE ‒ short‐ and long‐term data (low certainty).

1 finding from 1 review

SHORT vs LONG HOSPITAL STAY

No clinically important changes in specific symptoms ‐ positive and negative symptoms of schizophrenia (long term) Mental state: Not improved ‐ by 2 years ‐ as measured by PEF scale PEF scale · patients with people with severe mental illnesses

It is very uncertain whether SHORT changes no clinically important changes in specific symptoms ‐ positive and… compared with LONG HOSPITAL STAY (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Mental state: psychotic symptoms Average total score (PANSS, higher score = worse, scale from 30‐210) Long‐term (up to 7 years) · people in the prodromal stage of psychosis
1 finding from 1 review

Omega‐3 vs placebo

Satisfaction with treatment: 1. Leaving the study early ‐ long term · people in the prodromal stage of psychosis

Group A: omega‐3 fatty acids showed no clear difference in satisfaction with treatment: leaving the study early Long‐term… compared with placebo (low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy + supportive therapy vs supportive therapy

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes prodromal symptoms: transition to psychosis Long‐term (events) compared with supportive therapy (very low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy (specific preventive intervention) + needs‐based intervention + risperidone vs needs‐based intervention

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes prodromal symptoms: transition to psychosis Endpoint data (events)… compared with needs‐based intervention (very low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy (specific preventive intervention) + needs‐based intervention + risperidone vs needs‐based intervention

Satisfaction with treatment: 1. Leaving the study early ‐ long term · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes satisfaction with treatment: leaving the study early (events)… compared with needs‐based intervention (very low certainty).

1 finding from 1 review

Cognitive training vs active control

Satisfaction with treatment: 1. Leaving the study early ‐ long term · people in the prodromal stage of psychosis

It is very uncertain whether group C other: cognitive training changes satisfaction with treatment: leaving the study early Endpoint data… compared with active control (tablet games) (very low certainty).

1 finding from 1 review

Group C other: family treatment vs enhanced care

Prodromal symptoms: transition to psychosis FACT Long‐term · people in the prodromal stage of psychosis

It is very uncertain whether group C other: family treatment changes prodromal symptoms: transition to psychosis FACT Long‐term compared with enhanced care (very low certainty).

1 finding from 1 review