Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

71 questions · 71 findings · 14 reviews · Heart

No studies found 8 · 11.3%GRADE not reported 1 · 1.4%Very low 20 · 28.2%Low 19 · 26.8%Moderate 15 · 21.1%High 8 · 11.3%

Prophylactic corticosteroids vs placebo or no corticosteroids

Mortality within the longest · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids showed no clear difference in all‐cause mortality (during the index hospital admission, or within… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review

Prophylactic corticosteroids vs placebo or no corticosteroids

Pulmonary complications (as defined by study authors, including pneumonia, embolism, reduced pulmonary function, prolonged ventilation, and pleural effusion, during the index hospital admission) · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids may leads to lower pulmonary complications (as defined by study authors, including… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review

Ultrafiltration (UF) vs usual care

New initiation of renal replacement therapy – at longest available · people with AHF

Ultrafiltration (UF) showed no clear difference in new initiation of renal replacement therapy – at longest available compared with usual care (UC) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs control

Cardiovascular mortality · health problem or population

Summary of findings table ‐ Psychological treatment showed no clear difference in cardiovascular mortality ‐ long‐term compared with control; GRADE not reported.

1 finding from 1 review

Levosimendan vs dobutamine

All‐cause long‐term mortality: range 4 to 12 months · people with cardiogenic shock or low cardiac output syndrome

Levosimendan showed no clear difference in all‐cause long‐term mortality: range 4 to 12 months compared with dobutamine (low certainty).

1 finding from 1 review

Levosimendan vs placebo

All‐cause long‐term mortality: range 4 to 6 months · adults with cardiogenic shock or low cardiac output syndrome

It is very uncertain whether levosimendan changes all‐cause long‐term mortality: range 4 to 6 months compared with placebo (very low certainty).

1 finding from 1 review

Complete revascularisation vs culprit‐only revascularisation

Long‐term all‐cause mortality (≥ 1 year after the intervention) · people with STEMI and MVD.

It is very uncertain whether complete revascularisation changes long‐term all‐cause mortality (≥ 1 year after the intervention) compared with culprit‐only revascularisation (very low certainty).

1 finding from 1 review

Complete revascularisation vs culprit‐only revascularisation

Cardiovascular mortality · people with STEMI and MVD.

It is very uncertain whether complete revascularisation changes long‐term cardiovascular mortality (≥ 1 year after the intervention) compared with culprit‐only revascularisation (very low certainty).

1 finding from 1 review

Complete revascularisation vs culprit‐only revascularisation

Myocardial infarction · people with STEMI and MVD.

It is very uncertain whether complete revascularisation changes long‐term myocardial infarction (≥ 1 year after the intervention) compared with culprit‐only revascularisation (very low certainty).

1 finding from 1 review

Complete revascularisation vs culprit‐only revascularisation

Overall adverse events (pooled short and long term) · people with STEMI and MVD.

It is very uncertain whether complete revascularisation changes overall adverse events (pooled short and long term) compared with culprit‐only revascularisation (very low certainty).

1 finding from 1 review

Complete revascularisation vs culprit‐only revascularisation

Long‐term revascularisation (≥ 1 year after the intervention) · people with STEMI and MVD.

It is very uncertain whether complete revascularisation changes long‐term revascularisation (≥ 1 year after the intervention) compared with culprit‐only revascularisation (very low certainty).

1 finding from 1 review

Intervention not reported

Mortality (all cause) Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention may leads to lower mortality (all cause) Long‐term (low certainty).

1 finding from 1 review