Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

36 questions · 41 findings · 7 reviews

No studies found 8 · 19.5%GRADE not reported 9 · 22%Very low 13 · 31.7%Low 2 · 4.9%Moderate 3 · 7.3%High 6 · 14.6%

Levofloxacin vs usual care

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with endocarditis caused by Staphylococcus aureus

It is very uncertain whether levofloxacin changes all‐cause mortality during hospital stay and all‐cause mortality at… compared with standard treatment (very low certainty).

1 finding from 1 review

Levofloxacin vs ciprofloxacin

Microbiological efficacy ‐ pathogen eradication · patients with chronic bacterial prostatitis

It is very uncertain whether levofloxacin changes microbiological efficacy ‐ pathogen eradication compared with ciprofloxacin (very low certainty).

1 finding from 1 review

Levofloxacin vs fluoroquinolones

Microbiological efficacy ‐ pathogen eradication · patients with chronic bacterial prostatitis

It is very uncertain whether levofloxacin changes microbiological efficacy ‐ pathogen eradication compared with comparator fluoroquinolone (very low certainty).

1 finding from 1 review

Levofloxacin vs fluoroquinolones

Adverse effects of treatment ‐ any adverse effects · patients with chronic bacterial prostatitis

Levofloxacin showed no clear difference in adverse effects of treatment ‐ any adverse effects compared with comparator fluoroquinolone (moderate certainty).

1 finding from 1 review

Levofloxacin vs ciprofloxacin

Clinical efficacy ‐ cure or improvement at · patients with chronic bacterial prostatitis

Levofloxacin showed no clear difference in clinical efficacy ‐ cure or improvement at end of treatment compared with ciprofloxacin (low certainty).

2 findings from 1 review

Levofloxacin vs ciprofloxacin

Adverse effects of treatment ‐ any adverse effects · patients with chronic bacterial prostatitis

Levofloxacin showed no clear difference in adverse effects of treatment ‐ any adverse effects compared with ciprofloxacin (moderate certainty).

1 finding from 1 review

Levofloxacin + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis

Levofloxacin + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

2 findings from 1 review

Levofloxacin + SRP vs SRP

Probing pocket depth · Adults with chronic periodontitis

Levofloxacin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

2 findings from 1 review

Levofloxacin + SRP vs SRP

Clinical attachment level (CAL) · Adults with chronic periodontitis

Levofloxacin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

2 findings from 1 review

Summary of findings: levofloxacin for inhalation solution vs tobramycin

Pulmonary exacerbations: number of hospitalisations due to respiratory exacerbations · adults and children aged over 12 with CF and P aeruginosa

Summary of findings: levofloxacin for inhalation solution leads to lower pulmonary exacerbations: number of hospitalisations due to… compared with tobramycin (high certainty).

1 finding from 1 review