Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

31 questions · 32 findings · 5 reviews

No studies found 7 · 21.9%GRADE not reported 14 · 43.8%Very low 4 · 12.5%Low 6 · 18.8%Moderate 1 · 3.1%High 0 · 0%

Ketoconazole vs placebo

Failure to achieve complete resolution Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole may leads to lower failure to achieve complete resolution Clinical assessment compared with placebo (low certainty).

1 finding from 1 review

Ketoconazole vs placebo

Side effects Self report · patients with seborrhoeic dermatitis

It is very uncertain whether ketoconazole changes side effects Self report compared with placebo (very low certainty).

1 finding from 1 review

Ketoconazole vs steroids

Failure to achieve complete resolution (combined for face and scalp) Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole showed no clear difference in failure to achieve complete resolution (combined for face and scalp)… compared with steroids (low certainty).

1 finding from 1 review

Ketoconazole vs steroids

Side effects (combined for face and scalp) Self report · patients with seborrhoeic dermatitis

Ketoconazole probably leads to lower side effects (combined for face and scalp) Self report compared with steroids (moderate certainty).

1 finding from 1 review

Ketoconazole vs ciclopirox

Failure to achieve complete resolution ‐ Face only Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole showed no clear difference in failure to achieve complete resolution ‐ Face only Clinical assessment compared with ciclopirox (low certainty).

1 finding from 1 review

Ketoconazole vs ciclopirox

Failure to achieve complete resolution (long term) ‐ Face only Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole showed no clear difference in failure to achieve complete resolution (long term) ‐ Face only… compared with ciclopirox (low certainty).

1 finding from 1 review

Ketoconazole vs ciclopirox

Side effects ‐ Scalp only Self reported · patients with seborrhoeic dermatitis

It is very uncertain whether ketoconazole changes side effects ‐ Scalp only Self reported compared with ciclopirox (very low certainty).

1 finding from 1 review

Complete cure for ketoconazole vs griseofulvin

Proportion of participants with complete cure · children infected with Trichophyton

Complete cure for ketoconazole showed no clear difference in proportion of participants with complete cure compared with griseofulvin (low certainty).

2 findings from 1 review

Ketoconazole vs placebo

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Ketoconazole (absorbed from GI tract) showed no clear difference in mycological: eradication of oral candidiasis compared with placebo; GRADE not reported.

1 finding from 1 review

Absorbed drug (fluconazole or ketoconazole) vs Antifungal drugs not absorbed from GI tract

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Absorbed drug (fluconazole or ketoconazole) led to higher mycological: eradication of oral candidiasis compared with drug not absorbed from GI tract (amphotericin B or nystatin); GRADE not reported.

1 finding from 1 review

Absorbed drug (fluconazole or ketoconazole) vs Antifungal drugs not absorbed from GI tract

Clinical: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Absorbed drug (fluconazole or ketoconazole) led to higher clinical: eradication of oral candidiasis compared with drug not absorbed from GI tract (amphotericin B or nystatin); GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole,… showed no clear difference in systemic fungal infection compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Relief of dysphagia · Patients with cancer receiving chemotherapy and/or radiotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Empirical antifungal treatment · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole,… led to lower empirical antifungal treatment compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Cost of oral care · Patients with cancer receiving chemotherapy and/or radiotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Good compliance · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole,… showed no clear difference in good compliance compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review