Cochrane · systematic review · CD004685
Systemic antifungal therapy for tinea capitis in children
Chen, X, Jiang, X, Yang, M, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SkinAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
15
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 6.7%Low 10 · 66.7%Moderate 4 · 26.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Complete cure and adverse events for terbinafine versus griseofulvin in children with tinea capitis
Population: children with tinea capitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants with complete cure Complete cure and adverse events for terbinafine vs griseofulvin | RR 1.06 [0.98, 1.15] | 3 studies · 328 participants | Low Downgraded: risk of bias, imprecision |
Proportion of participants with complete cure Complete cure and adverse events for terbinafine vs griseofulvin | RR 1.18 [0.74, 1.88] | 1 study · 1006 participants | Low Downgraded: risk of bias |
Proportion of participants with complete cure Complete cure and adverse events for terbinafine vs griseofulvin | RR 0.68 [0.53, 0.86] | 2 studies · 334 participants | Moderate Downgraded: risk of bias |
Proportion of participants with complete cure Complete cure and adverse events for terbinafine vs griseofulvin | RR 0.45 [0.15, 1.35] | 1 study · 21 participants | Low Downgraded: risk of bias, imprecision |
Adverse events attributed to the study drugs Complete cure and adverse events for terbinafine vs griseofulvin | RR 1.11 [0.79, 1.57] | 1 study · 1549 participants | Moderate Downgraded: risk of bias |
Severe adverse events Complete cure and adverse events for terbinafine vs griseofulvin | RR 0.97 [0.24, 3.88] | 1 study · 1549 participants | Moderate Downgraded: risk of bias |
Complete cure for itraconazole versus griseofulvin in children infected with Trichophyton and Microsporum
Population: children infected with Trichophyton and Microsporum
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants with complete cure Complete cure for itraconazole vs griseofulvin | RR 0.92 [0.81, 1.05] | 2 studies · 134 participants | Very low Downgraded: risk of bias, inconsistency |
Complete cure for itraconazole versus terbinafine in children infected with Trichophyton
Population: children infected with Trichophyton
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants with complete cure Complete cure for itraconazole vs terbinafine | RR 0.93 [0.72, 1.19] | 2 studies · 160 participants | Low Downgraded: risk of bias |
Complete cure for ketoconazole versus griseofulvin in children infected with Trichophyton
Population: children infected with Trichophyton
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants with complete cure Complete cure for ketoconazole vs griseofulvin | RR 0.76 | 1 study · 62 participants | Low Downgraded: risk of bias |
Proportion of participants with complete cure Complete cure for ketoconazole vs griseofulvin | RR 0.92 [0.81, 1.03] | 1 study · 62 participants | Low Downgraded: risk of bias |
Complete cure for fluconazole versus griseofulvin in children with tinea capitis
Population: children with tinea capitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants with complete cure Complete cure for fluconazole vs griseofulvin | RR 0.92 [0.81, 1.05] | 3 studies · 615 participants | Moderate Downgraded: risk of bias |
Proportion of participants with complete cure Complete cure for fluconazole vs griseofulvin | RR 1.06 [0.77, 1.46] | 1 study · 361 participants | Low Downgraded: risk of bias |
Complete cure for fluconazole versus terbinafine in children infected with Trichophyton
Population: children infected with Trichophyton
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
The proportion of participants with complete cure Complete cure for fluconazole vs terbinafine | RR 0.87 [0.75, 1.01] | 1 study · 100 participants | Low Downgraded: risk of bias |
Complete cure for fluconazole versus itraconazole in children infected with Trichophyton
Population: children infected with Trichophyton
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants with complete cure Complete cure for fluconazole vs itraconazole | RR 1 [0.83, 1.2] | 1 study · 100 participants | Low Downgraded: risk of bias |
Complete cure for different durations of fluconazole in children infected with T. tonsurans and M. canis
Population: children infected with T. tonsurans and M. canis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants with complete cure | RR 0.88 [0.68, 1.14] | 1 study · 491 participants | Low Downgraded: risk of bias |