Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

280 questions · 280 findings · 13 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 127 · 45.4%GRADE not reported 3 · 1.1%Very low 85 · 30.4%Low 46 · 16.4%Moderate 19 · 6.8%High 0 · 0%

Psychological interventions vs usual care

Adherence to inhaled therapies cMPR · children, adolescents or adults with CF

Summary of findings: psychological interventions probably leads to higher adherence to inhaled therapies: % of prescribed inhaled therapies… compared with usual care (moderate certainty).

1 finding from 1 review

Psychological interventions vs usual care

Treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) compared with usual care (low certainty).

1 finding from 1 review

Psychological interventions vs usual care

Treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) compared with usual care (low certainty).

1 finding from 1 review

Motivational interventions to improve adherence to airway clearance treatment for people with CF ‐ self‐selected music vs no music

Adherence · people with CF

It is very uncertain whether motivational interventions to improve adherence to airway clearance… changes adherence to treatment Morisky‐Green questionnaire (number of… compared with no music (very low certainty).

1 finding from 1 review

Motivational interventions to improve adherence to airway clearance treatment for people with CF ‐ self‐selected music vs no music

Frequency of hospitalisation for respiratory infection · people with CF

It is very uncertain whether motivational interventions to improve adherence to airway clearance… changes frequency of hospitalisation for respiratory infection compared with no music (very low certainty).

1 finding from 1 review

Motivational interventions to improve adherence to airway clearance treatment for people with CF ‐ specifically‐composed music vs no music

Adherence · people with CF

It is very uncertain whether motivational interventions to improve adherence to airway clearance… changes adherence to treatment Morisky‐Green questionnaire (number of… compared with no music (very low certainty).

1 finding from 1 review