Findings

What do systematic reviews say?

6 questions · 6 findings · 3 reviews · Airways · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 3 · 50%High 0 · 0%

Intermittent ICS vs placebo

Exacerbations requiring oral corticosteroids ‐ School‐age children · School‐aged children and adults

Intermittent ICS showed no clear difference in exacerbations requiring oral corticosteroids ‐ School‐age children compared with placebo (low certainty).

1 finding from 1 review

Intermittent inhaled corticosteroid therapy versus placebo for persistent asthma in children and adults 2015 · Cochrane Headline outcomes only
OR 0.57 [0.29, 1.12]
1 study · 145 participants
Low

Intermittent ICS vs placebo

Exacerbations requiring oral corticosteroids ‐ adults · School‐aged children and adults

Intermittent ICS showed no clear difference in exacerbations requiring oral corticosteroids ‐ adults compared with placebo (low certainty).

1 finding from 1 review

Intermittent inhaled corticosteroid therapy versus placebo for persistent asthma in children and adults 2015 · Cochrane Headline outcomes only
OR 0.1 [0.01, 1.95]
1 study · 240 participants
Low

Intermittent ICS vs placebo

Mean exacerbations requiring a course of oral corticosteroids · Preschool children (<6 years)

Intermittent ICS probably leads to lower exacerbations requiring oral corticosteroids compared with placebo (moderate certainty).

1 finding from 1 review

Intermittent inhaled corticosteroid therapy versus placebo for persistent asthma in children and adults 2015 · Cochrane Headline outcomes only
OR 0.48 [0.31, 0.73]
4 studies · 490 participants
Moderate

Intermittent LTRA vs placebo

Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
RR 0.85 [0.64, 1.14]
2 studies · 343 participants
Moderate

Intermittent 'as needed' ICS vs daily ICS

Number of participants experiencing one or more episode requiring treatment with oral steroids · Children and adults with persistent asthma.

Intermittent 'as needed' ICS showed no clear difference in patients with 1 or more exacerbations requiring oral corticosteroids… compared with daily ICS (low certainty).

1 finding from 1 review

Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults 2013 · Cochrane Headline outcomes only
RR 1.07 [0.87, 1.32]
7 studies · 1204 participants
Low

Maintenance LTRA vs placebo

Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 1.2 [0.7, 2.06]
1 study · 347 participants
Moderate