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What do systematic reviews say?

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Evidence found and GRADE certainty

264 questions · 277 findings · 45 reviews

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No studies found 80 · 28.9%GRADE not reported 8 · 2.9%Very low 96 · 34.7%Low 50 · 18.1%Moderate 40 · 14.4%High 3 · 1.1%

Increased vs stable doses of inhaled corticosteroids

Treatment failure ‐ need for systemic corticosteroids (ITT) · adults and children with chronic asthma

Increased showed no clear difference in treatment failure: need for systemic corticosteroids (ITT) compared with stable doses of inhaled corticosteroids (moderate certainty).

1 finding from 1 review

Increased vs stable doses of inhaled corticosteroids

Treatment failure ‐ need for systemic corticosteroids (of those starting inhaler) · adults and children with chronic asthma

It is very uncertain whether increased changes treatment failure: need for systemic corticosteroids (of those… compared with stable doses of inhaled corticosteroids (very low certainty).

1 finding from 1 review

Increased vs stable doses of inhaled corticosteroids

Unscheduled physician visits 44 weeks · adults and children with chronic asthma

Increased showed no clear difference in unscheduled physician visits 44 weeks compared with stable doses of inhaled corticosteroids (low certainty).

1 finding from 1 review

Increased vs stable doses of inhaled corticosteroids

Serious adverse events 48 weeks · adults and children with chronic asthma

It is very uncertain whether increased changes serious adverse events 48 weeks compared with stable doses of inhaled corticosteroids (very low certainty).

1 finding from 1 review

Increased vs stable doses of inhaled corticosteroids

Non‐serious adverse events 43 weeks · adults and children with chronic asthma

It is very uncertain whether increased changes non‐serious adverse events 43 weeks compared with stable doses of inhaled corticosteroids (very low certainty).

1 finding from 1 review

Abundant water intake vs standard water intake

Stone recurrence (assessed as symptomatic renal colic/stone expulsion episodes and imaging) · participants with a prior history of nephrolithiasis

Increased water intake may leads to lower stone recurrence (assessed as symptomatic renal colic/stone… compared with standard water intake (low certainty).

1 finding from 1 review

Abundant water intake vs standard water intake

Time to recurrence · participants with a prior history of nephrolithiasis

Increased water intake may leads to lower time to recurrence (absolute event rate based on 5‐year compared with standard water intake (low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with an increased creatinine level · people with TSC

The intervention probably leads to lower number of participants with an increased creatinine level (moderate certainty).

1 finding from 1 review