Findings

What do systematic reviews say?

8 questions · 8 findings · 3 reviews · Cystic Fibrosis and Genetic Disorders · Headline outcomes only

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No studies found 1 · 12.5%GRADE not reported 0 · 0%Very low 4 · 50%Low 2 · 25%Moderate 1 · 12.5%High 0 · 0%

Etilefrine vs placebo

Immediate side effects of treatment (palpitations) · men and boys with SCD and stuttering priapism

It is very uncertain whether etilefrine changes immediate side effects of treatment (palpitations) compared with placebo (very low certainty).

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 1.64 [0.62, 4.3]
1 study · 23 participants
Very low

Etilefrine vs placebo

Immediate side effects of treatment (tachycardia) · men and boys with SCD and stuttering priapism

It is very uncertain whether etilefrine changes immediate side effects of treatment (tachycardia) compared with placebo (very low certainty).

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 2.18 [0.71, 6.68]
1 study · 23 participants
Very low

Ephedrine vs placebo

Immediate side effects of treatment with 30 mg ephedrine (palpitations) · men and boys with SCD and stuttering priapism

It is very uncertain whether ephedrine changes immediate side effects of treatment with 30 mg ephedrine… compared with placebo (very low certainty).

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 1 [0.32, 3.1]
1 study · 24 participants
Very low

Ephedrine vs placebo

Immediate side effects of treatment (tachycardia) · men and boys with SCD and stuttering priapism

It is very uncertain whether ephedrine changes immediate side effects of treatment with 30 mg ephedrine (tachycardia) compared with placebo (very low certainty).

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.67 [0.13, 3.3]
1 study · 24 participants
Very low

Silboesterol vs placebo

Immediate side effects of treatment · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sildenafil vs placebo

Immediate side effects of treatment · men and boys with SCD and stuttering priapism

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Low

Inhalation before vs during airway clearance techniques

Expectorated secretions (sputum wet weight) · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 26 participants
Low

Intervention not reported

Family relationship Pre‐intervention and post‐intervention assessment Home visits and training session for family members Patient‐caregiver relationships assessed pre‐intervention and immediately post‐intervention. · caregivers of patients with sickle cell disease

1 finding from 1 review

Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related… 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 76 participants
Moderate