What do systematic reviews say?

Etilefrine vs placebo

It is very uncertain whether etilefrine changes immediate side effects of treatment (palpitations) compared with placebo (very low certainty).

• Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
  RR 1.64 [0.62, 4.3]
  1 study · 23 participants
  Very low

Etilefrine vs placebo

It is very uncertain whether etilefrine changes immediate side effects of treatment (tachycardia) compared with placebo (very low certainty).

• Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
  RR 2.18 [0.71, 6.68]
  1 study · 23 participants
  Very low

Ephedrine vs placebo

It is very uncertain whether ephedrine changes immediate side effects of treatment with 30 mg ephedrine… compared with placebo (very low certainty).

• Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
  RR 1 [0.32, 3.1]
  1 study · 24 participants
  Very low

Ephedrine vs placebo

It is very uncertain whether ephedrine changes immediate side effects of treatment with 30 mg ephedrine (tachycardia) compared with placebo (very low certainty).

• Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
  RR 0.67 [0.13, 3.3]
  1 study · 24 participants
  Very low

Silboesterol vs placebo

The review found no eligible studies for this question.

• Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Sildenafil vs placebo

• Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 13 participants
  Low

Inhalation before vs during airway clearance techniques

• Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 26 participants
  Low

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

The review found no eligible studies for this question.

• Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease… 2019 · Cochrane All outcomes

  Immediate (<24 h) and delayed (24 h to 10 days)
  This outcome was not reported in either of the trials.
  0 studies
  No studies found

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… led to lower number of immediate and delayed postoperative bleeding episodes… compared with placebo (placebo solution/mouthwash); GRADE not reported.

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes

  Immediate (<24 h) and delayed (24 h to 10 days); bleeds occurred 1, 3 or 5 days postoperatively
  RD -0.22 [-0.35, -0.10]
  1 study · 89 participants
  GRADE not reported

Intervention not reported

• Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 76 participants
  Moderate