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Evidence found and GRADE certainty

132 questions · 147 findings · 29 reviews · Neonatal · Headline outcomes only

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No studies found 41 · 27.9%GRADE not reported 4 · 2.7%Very low 29 · 19.7%Low 43 · 29.3%Moderate 19 · 12.9%High 11 · 7.5%

Summary of findings table ‐ Early amino acids vs Late amino acids

Growth during the first month of life · preterm born neonates
3 findings from 1 review

Summary of findings table ‐ Early amino acids vs Late amino acids

Neurodevelopmental outcomes · preterm born neonates

Summary of findings table ‐ Early amino acids showed no clear difference in neurodevelopmental outcome assessed by any standard tool compared with late amino acids (low certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

Death before 1 year of age · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in infant death (age < 1 year) compared with control (low certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

Bronchopulmonary dysplasia · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in bronchopulmonary dysplasia (at 36 to 38 weeks' PMA) compared with control (moderate certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

ROP, stage ≥ 3 or ≥ 2 · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in ROP, stage ≥ 3 or ≥ 2 compared with control (moderate certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

Sepsis · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in sepsis (early or late onset) compared with control (moderate certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

Necrotizing enterocolitis (suspected or proven) · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in necrotizing enterocolitis (suspected or proven) compared with control (moderate certainty).

1 finding from 1 review

Inositol supplementation to preterm infants (repeat doses in any amount and any duration of treatment) vs control

Severe intraventricular haemorrhage · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation to preterm infants (repeat doses in any… showed no clear difference in intraventricular haemorrhage, grade > 2 compared with control (moderate certainty).

1 finding from 1 review

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

BPD or death by it prior to 37 weeks' PMA (outcomes collected through first event: death, hospital discharge, hospital transfer, or 120 days after birth) · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation IV initially followed by enteral… showed no clear difference in BPD or death by it prior to 37 weeks' PMA (outcomes collected… compared with placebo (high certainty).

1 finding from 1 review

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

Severe (grade 3 or greater) intraventricular hemorrhage (IVH) on cranial ultrasound ‐ not reported · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation IV initially followed by enteral… showed no clear difference in severe IVH (grade 3 or 4) compared with placebo (moderate certainty).

1 finding from 1 review

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

Any late‐onset sepsis ‐ all infants · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation IV initially followed by enteral… showed no clear difference in late‐onset sepsis (> 72 hours of age) compared with placebo (high certainty).

1 finding from 1 review

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

Necrotizing enterocolitis (suspected or proven) · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation IV initially followed by enteral… showed no clear difference in suspected or proven NEC compared with placebo (high certainty).

1 finding from 1 review

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

Type 1 ROP or death before determination of ROP outcome using the adjudicated ROP outcome · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation IV initially followed by enteral… showed no clear difference in type 1 ROP or death before determination of ROP outcome using the… compared with placebo (moderate certainty).

1 finding from 1 review

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

Type 1 ROP including adjudicated ROP outcome · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation IV initially followed by enteral… showed no clear difference in type 1 ROP including adjudicated ROP outcome compared with placebo (moderate certainty).

1 finding from 1 review