What do systematic reviews say?

Fluocinonide in adhesive base vs placebo

Fluocinonide in adhesive base showed no clear difference in physician Global Assessment (clinical signs, complete response) compared with placebo; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  RR 4.67 [0.24, 88.96]
  1 study · 27 participants
  GRADE not reported

Fluocinonide in adhesive base vs placebo

Fluocinonide in adhesive base showed no clear difference in partial response (>33% improvement) compared with placebo; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  RR 3.00 [0.62, 14.62]
  1 study · 27 participants
  GRADE not reported

Fluocinonide in adhesive base vs placebo

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  Table 3 (Side-effects). Voute 1993: no side-effects during the study and follow-up period.
  1 study · 27 participants
  GRADE not reported

0.1% triamcinolone acetonide in orabase vs ciclosporin

0.1% triamcinolone acetonide in orabase showed no clear difference in physician Global Assessment (Thongprasom score) compared with ciclosporin solution; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD 0.61 [-0.79, 2.01]
  1 study · 11 participants
  GRADE not reported

0.1% triamcinolone acetonide in orabase vs ciclosporin

0.1% triamcinolone acetonide in orabase led to higher pain reduction (VAS 0-100) compared with ciclosporin solution; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD 45.17 [8.73, 81.61]
  1 study · 11 participants
  GRADE not reported

0.1% triamcinolone acetonide in orabase vs ciclosporin

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  Table 3 (Side-effects). Yoke 2006: no significant adverse events; transient burning sensation upon initial application with both treatments.
  1 study · 15 participants
  GRADE not reported

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No studies reported this outcome.
  0 studies
  No studies found

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  None of the included studies assessed the effectiveness of treatments of genital ELP; thus, this outcome was not reported.
  0 studies
  No studies found

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No studies reported this outcome.
  0 studies
  No studies found

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No studies reported this outcome.
  0 studies
  No studies found

Betamethasone oral mini-pulse therapy vs Topical triamcinolone acetonide paste

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  Table 3 (Side-effects). Malhotra 2008: betamethasone oral mini-pulse - transient oedema over the face (7), oedema over hands and feet (4), epigastric discomfort (7), weakness/fatigue (5), loose stools (1), headache…
  1 study · 22 participants
  GRADE not reported

Betamethasone oral mini-pulse therapy vs Topical triamcinolone acetonide paste

Betamethasone oral mini-pulse therapy led to higher physician Global Assessment (clinical severity, 0-12 score) compared with topical triamcinolone acetonide 0.1% paste; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes

  24 weeks
  MD 1.78 [0.17, 3.39]
  1 study · 22 participants
  GRADE not reported