Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 30 findings · 1 reviews · Pain, Palliative and Supportive Care

No studies found 15 · 50%GRADE not reported 0 · 0%Very low 9 · 30%Low 5 · 16.7%Moderate 1 · 3.3%High 0 · 0%

Summary of findings: lorazepam plus haloperidol vs placebo plus haloperidol

Specific behaviour ‐ agitation · terminally ill adults with severe delirium

It is very uncertain whether summary of findings: lorazepam plus haloperidol changes agitation within 24 hoursc compared with placebo plus haloperidol (very low certainty).

2 findings from 1 review

Summary of findings: lorazepam plus haloperidol vs placebo plus haloperidol

Adverse events including extrapyramidal effects · terminally ill adults with severe delirium

It is very uncertain whether summary of findings: lorazepam plus haloperidol changes adverse events including extrapyramidal effectsd compared with placebo plus haloperidol (very low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

Symptoms of delirium within 24 hoursa · terminally ill adults with delirium

Summary of findings: haloperidol showed no clear difference in symptoms of delirium within 24 hoursa compared with placebo (low certainty).

1 finding from 1 review

HALOPERIDOL vs OLANZAPINE

Symptoms of delirium within 24 hoursa · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes symptoms of delirium within 24 hoursa compared with olanzapine (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OLANZAPINE

Symptoms of delirium between 24 and 48 hoursa · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes symptoms of delirium between 24 and 48 hoursa compared with olanzapine (very low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

Symptoms of delirium between 24 and 48 hoursa · terminally ill adults with delirium

Summary of findings: haloperidol showed no clear difference in symptoms of delirium between 24 and 48 hoursa compared with placebo (low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Symptoms of delirium between 24 and 48 hoursa · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes symptoms of delirium between 24 and 48 hoursa compared with chlorpromazine (very low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Adverse events including extrapyramidal effects · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes adverse events including extrapyramidal effectsc compared with chlorpromazine (very low certainty).

1 finding from 1 review

HALOPERIDOL vs lorazepam

Symptoms of delirium between 24 and 48 hoursa · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes symptoms of delirium between 24 and 48 hoursa compared with lorazepam (very low certainty).

1 finding from 1 review

HALOPERIDOL vs lorazepam

Adverse events including extrapyramidal effects · terminally ill adults with delirium

It is very uncertain whether summary of findings: haloperidol changes adverse events including extrapyramidal effectsc compared with lorazepam (very low certainty).

1 finding from 1 review