Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

347 questions · 354 findings · 22 reviews

No studies found 100 · 28.2%GRADE not reported 37 · 10.5%Very low 115 · 32.5%Low 64 · 18.1%Moderate 23 · 6.5%High 15 · 4.2%

HALOPERIDOL vs COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE

Global outcome: general ‐ no improvement · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: general ‐ no overall improvement compared with COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Tranquilisation or asleep ‐ not asleep by 3 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes tranquillisation or asleep ‐ not asleep by 3 hours compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Repeated need for rapid tranquillisation ‐ needing additional injection during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes repeated need for rapid tranquillisation ‐ needing additional… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Global outcome: no overall improvement ‐ at 30 minutes · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: no overall improvement ‐ at 30 minutes compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Adverse effects: specific ‐ dystonia · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ dystonia (only reported if occurred in… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Adverse effects: Specific ‐ hypertonia/rigidity (only reported if occurred in ≥9%) during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ hypertonia/rigidity (only reported if… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Repeated need for tranquillisation ‐ not reported · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes repeated need for tranquillisation compared with COMBINATIONS: c. HALOPERIDOL + MIDAZOLAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: c. HALOPERIDOL + PROMETHAZINE

Repeated need for tranquillisation ‐ not reported · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes repeated need for tranquillisation compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (very low certainty).

1 finding from 1 review