Findings

What do systematic reviews say?

35 questions · 35 findings · 5 reviews · Pain, Palliative and Supportive Care

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No studies found 9 · 25.7%GRADE not reported 0 · 0%Very low 14 · 40%Low 1 · 2.9%Moderate 10 · 28.6%High 1 · 2.9%

Gabapentin vs placebo

Participant‐reported pain relief of 50% or greater · adults with postherpetic neuralgia

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 2031 participants
Moderate

Gabapentin vs placebo

Withdrawals due to adverse events · adults with neuropathic pain

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
22 studies · 4346 participants
High

Gabapentin vs placebo

Serious adverse events · adults with neuropathic pain

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
19 studies · 3948 participants
Moderate

Gabapentin vs placebo

Death · adults with neuropathic pain

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Gabapentin vs placebo

IMMPACT definition ‐ any substantial pain benefit · adults with postherpetic neuralgia

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 2260 participants
Moderate

Gabapentin vs placebo

Patient Global Impression of Change much or very much improved · adults with postherpetic neuralgia

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 2013 participants
Moderate

Gabapentin vs placebo

IMMPACT definition ‐ any at least moderate pain benefit · adults with postherpetic neuralgia

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 2260 participants
Moderate

Gabapentin vs placebo

Participant‐reported pain relief of 50% or greater · people with diabetic peripheral neuropathy

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1331 participants
Moderate

Gabapentin vs placebo

'Substantial benefit' (≥ 50% reduction in pain or PGIC very much improved) · people with diabetic peripheral neuropathy

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1331 participants
Moderate

Gabapentin vs placebo

Patient Global Impression of Change much or very much improved · people with diabetic peripheral neuropathy

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 695 participants
Moderate

Gabapentin vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · people with diabetic peripheral neuropathy

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1439 participants
Moderate

Gabapentin vs placebo

Proportion of participants experiencing adverse events · adults with neuropathic pain

1 finding from 1 review

Gabapentin for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
18 studies · 4279 participants
Moderate

Gabapentin vs placebo

At least 30% reduction in pain · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Very low

Gabapentin vs placebo

At least 50% reduction in pain · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Gabapentin vs placebo

PGIC ‐ any category of "better" at 12 weeks · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Very low

Gabapentin vs placebo

Withdrawals due to adverse events · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Very low

Gabapentin vs placebo

Serious adverse events · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Very low

Gabapentin vs placebo

Deaths · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Very low

Gabapentin vs amitriptyline

Participant‐reported pain relief of 30% or greater · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gabapentin vs amitriptyline

Participant‐reported pain relief of 50% or greater · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found