Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

16 questions · 16 findings · 3 reviews · ENT

No studies found 2 · 12.5%GRADE not reported 0 · 0%Very low 2 · 12.5%Low 7 · 43.8%Moderate 5 · 31.3%High 0 · 0%

Sinonasal debridement vs no debridement

Postoperative endoscopic appearance of the sinonasal surgical cavities: Lund‐Kennedy endoscopic score (range 1 to 10) · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

Sinonasal debridement showed no clear difference in postoperative endoscopic appearance of the sinonasal surgical… compared with no debridement (low certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Postoperative bleeding (place of packing or revision surgery within 14 days of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in postoperative bleeding (place of packing or revision surgery within… compared with placebo (saline solution or sterile water) (low certainty).

1 finding from 1 review

Sinonasal debridement vs no debridement

Significant adverse effects: significant bleeding requiring intervention, severe pain, iatrogenic injury · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

The review found no eligible studies for this question.

1 finding from 1 review

Sinonasal debridement vs no debridement

Adhesion rate · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

Sinonasal debridement may leads to lower adhesion rate compared with no debridement (low certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Overall rate of surgical complications · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in surgical complications compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review