Streptococcus mutans count · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
The antibacterial (S. mutans) effect of TiO2 nanoparticles was conflicting across two RCTs (ungraded).
1 finding from 1 review
Detection rate of oral pre-malignant and malignant lesions after referral (COE+vital rinsing vs COE alone) · Oral cavity cancer or potentially malignant disorder symptom-free individuals with tobacco habits
COE with vital rinsing (toluidine blue/tolonium chloride) showed no clear difference in detection rate of oral pre-malignant and malignant lesions after… compared with conventional oral examination (COE) alone (moderate certainty).
1 finding from 1 review
Dentist satisfaction (masking effect) · Patients with dental fluorosis
Resin infiltration alone produced greater dentist-rated masking than in-office bleaching alone in one study (MD 3.97, 95% CI 3.33 to 4.61; ungraded).
1 finding from 1 review
MD 3.97 [3.33, 4.61]
1 study
GRADE not reported
Costs: direct cost of treatment · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Locoregional control · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Concomitant (concurrent) chemoradiotherapy led to lower locoregional control, concurrent chemoradiotherapy (platinum +… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.
1 finding from 1 review
RR 0.75 [0.61, 0.93]
3 studies
GRADE not reported
Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Concomitant (concurrent) chemoradiotherapy led to lower disease-free survival, concurrent chemoradiotherapy vs radiotherapy… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.
1 finding from 1 review
HR 0.74 [0.67, 0.80]
13 studies
GRADE not reported
Overall survival, adjuvant concomitant chemoradiotherapy vs post-surgery radiotherapy alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Concomitant (concurrent) chemoradiotherapy probably leads to lower overall survival, concurrent chemoradiotherapy vs radiotherapy alone… compared with radiotherapy alone (non-resectable tumours) (moderate certainty).
1 finding from 1 review
COE with light-based detection (e.g. ViziLite Plus, Microlux/DL, VELscope, Identafi 3000) vs Conventional oral examination (COE) alone
Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
The review found no eligible studies for this question.
1 finding from 1 review
Specificity · Oral cavity cancer or potentially malignant disorder symptom-free individuals with tobacco habits
2 findings from 1 review
Specificity 0.91 [0.90, 0.91]
1 study · 4080 participants
Moderate
Specificity 0.92 [0.91, 0.93]
1 study · 3895 participants
Moderate
Sensitivity (COE alone arm) · Oral cavity cancer or potentially malignant disorder symptom-free individuals with tobacco habits
1 finding from 1 review
Dental anxiety (subjective and objective scores) · Children (ages 6-12) receiving pit-and-fissure sealants
Er:YAG laser preparation added to acid-etching did not increase children's dental anxiety versus acid-etching alone (P > 0.05; ungraded, single study).
1 finding from 1 review
Shindova 2018 (Er:YAG laser+acid vs acid-etching): no significant difference between initial and final subjective anxiety scores for the two groups; use of the Er:YAG laser did not provoke anxiety (P > 0.05).
1 study · 64 participants
GRADE not reported
Restoration survival · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
Rubber dam isolation and moisture control (alone or with saliva… may leads to higher survival rate of restorations (6 months) compared with cotton rolls (with or without saliva aspiration) (low certainty).
4 findings from 1 review
Show 1 more finding
Costs: treatment/operation time · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
It is very uncertain whether rubber dam isolation and moisture control (alone or with saliva… changes costs: treatment/operation time compared with cotton rolls (with or without saliva aspiration) (very low certainty).
1 finding from 1 review
Adverse events · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
The review found no eligible studies for this question.
1 finding from 1 review
Clinical evaluation of restoration's quality · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
1 finding from 1 review
Rubber dam isolation for restorative treatment in dental patients 2021 · Cochrane All outcomes6, 12, 18 months · Non-carious cervical lesions (composite restoration)
Loguercio 2015: no significant differences (P>0.05) in marginal staining and marginal adaptation of NCCL restorations between rubber dam and cotton rolls/retraction cords at 6, 12 and 18 months.
1 study · 30 participants
GRADE not reported
Participant acceptance/satisfaction · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
1 finding from 1 review
Rubber dam isolation for restorative treatment in dental patients 2021 · Cochrane All outcomesNon-carious cervical lesions (composite restoration)
Evidence did not support higher acceptance/preference for rubber dam than cotton rolls (P = 0.85 from binomial test on 28 participants; very low-certainty evidence) (Loguercio 2015).
1 study · 28 participants
Very low
Side effects · Adults, 16 years and older (dentate)
Harms and adverse outcomes (SoF): Neither study reported any information about adverse events. Jared 2005 assessed adverse events (participants issued a symptom diary) but did not report the findings; Graziani 2017 did…
1 study
GRADE not reported
Not estimable. Only 1 study reported adverse outcomes in terms of problems with the use of the assigned interdental cleaning aids. (See comment) In this comparison the single study (Jared 2005) asked participants to…
1 study
GRADE not reported
Incidence of initial enamel caries / white spot lesions adjacent to bracket base (subject level, dichotomized) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Adding a fluoride mouthrinse to daily fluoride toothpaste produced a small reduction in the incidence of initial caries/white spot lesions adjacent to brackets (pooled risk difference -0.07, 95% CI -0.14 to -0.01; 5 studies, 491 subjects), but the authors judged the overall evidence inconclusive (ungraded).
1 finding from 1 review
Side effects or other adverse events · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
No adverse effects were reported in any of the seven included studies (ungraded).
1 finding from 1 review
Masking effect (esthetic improvement) · Patients with dental fluorosis
Bleaching before resin infiltration did not improve masking of fluorosis compared with infiltration alone (MD -0.30, 95% CI -0.98 to 0.39; moderate certainty).
1 finding from 1 review
MD -0.30 [-0.98, 0.39]
2 studies
Moderate