Changes in the management of CMHDs Changes in drug therapy and referrals for specialist care · People with common mental health disorders1
1 finding from 1 review
Drug or alcohol use, or both following treatment completion ‐ Group‐based intervention As assessed by the ASI, TLFB or CIDI. High scores indicate greater symptom severity · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Intervention not reported
Drug or alcohol use, or both following treatment completion As assessed by the TLFB or CIDI. High scores indicate greater symptom severity · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Barnes Akathisia Scale LOCF at week 12 A physician‐assessed rating scale to assess the severity of drug‐induced akathisia Scale from 0 to 14 · patients with an acute manic or mixed episode
1 finding from 1 review
no estimate extracted
646 participants
Low
Simpson Angus Scale LOCF at week 12 A physician‐administered rating scale to measure drug‐induced Parkinsonism Scale from 0 to 40. · patients with an acute manic or mixed episode
1 finding from 1 review
no estimate extracted
646 participants
Low
Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder
1 finding from 1 review
Change in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder
It is very uncertain whether topiramate as add‐on therapy changes response to treatment with topiramate. Number of participants… compared with alternative drug (very low certainty).
1 finding from 1 review
Intervention not reported
Achieved recovery according to predetermined criteria (no longer meeting criteria for depression on K‐SADS or meeting a priori criteria for response on a depression checklist, assessed between 4 and 10 weeks of onset of treatment) · children and adolescents with depression
The intervention showed no clear difference in achieved recovery according to predetermined criteria (no longer… (low certainty).
1 finding from 1 review
Intervention not reported
Change in clinical global assessment scale scores (CGI scale or CGAS rated between 4 and 10 weeks of onset of treatment) · children and adolescents with depression
1 finding from 1 review
Intervention not reported
Number of withdrawals (occurring between 4 and 10 weeks of onset of treatment) · children and adolescents with depression
The intervention showed no clear difference in number of withdrawals (occurring between 4 and 10 weeks of onset of… (low certainty).
1 finding from 1 review
Abnormal Involuntary Movement Scale LOCF at week 12 A physician‐administered rating scale with 12 items to measure tardive dyskinesia Scale from 0 to 40 · patients with an acute manic or mixed episode
1 finding from 1 review
no estimate extracted
634 participants
Low