Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

46 questions · 46 findings · 4 reviews · Infectious Diseases · Headline outcomes only

No studies found 4 · 8.7%GRADE not reported 19 · 41.3%Very low 9 · 19.6%Low 9 · 19.6%Moderate 5 · 10.9%High 0 · 0%

Doxycycline vs tetracycline

Treatment failure · adults with scrub typhus

It is very uncertain whether doxycycline changes treatment failure compared with tetracycline (very low certainty).

1 finding from 1 review

Doxycycline vs tetracycline

Resolution of fever within 48 hours · adults with scrub typhus

Doxycycline showed no clear difference in resolution of fever within 48 hours compared with tetracycline (low certainty).

1 finding from 1 review

Doxycycline vs quinolones

Bacteriological failure · Adults and children with cholera diarrhoea

Doxycycline may leads to higher bacteriological failure compared with quinolones (low certainty).

1 finding from 1 review

Rifampicin vs doxycycline

Resolution of fever within 48 hours · adults with scrub typhus

It is very uncertain whether rifampicin changes resolution of fever within 48 hours compared with doxycycline (very low certainty).

1 finding from 1 review