Dexmedetomidine showed no clear difference in adverse event nausea and vomiting (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 261 participants
Low

Dexmedetomidine vs control or placebo medications

Hypotension · adults undergoing brain surgery

Dexmedetomidine may leads to lower adverse event hypotension (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Pharmacological interventions for the prevention of acute postoperative pain in adults following brain surgery 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 184 participants
Low

Other GA/adjunct vs sevoflurane anaesthesia

Emergence agitation—Dexmedetomidine · patients with emergence agitation

Other GA/adjunct leads to lower emergence agitation—Dexmedetomidine compared with sevoflurane anaesthesia (high certainty).

1 finding from 1 review

Effects of sevoflurane versus other general anaesthesia on emergence agitation in children 2014 · Cochrane Headline outcomes only
RR 0.37 [0.29, 0.47]
12 studies · 851 participants
High

Intervention not reported

Amount of 'rescue' opioid (intravenous morphine equivalents, mg) · adults having abdominal surgery

1 finding from 1 review

Perioperative dexmedetomidine for acute pain after abdominal surgery in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 259 participants
Very low

Intervention not reported

Postoperative pain (VAS 0 to 100 mm, visual analogue scale from 0 = no pain to 100 = worst imaginable pain) · adults having abdominal surgery

1 finding from 1 review

Perioperative dexmedetomidine for acute pain after abdominal surgery in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 259 participants
Very low

Intervention not reported

Postoperative sedation 12 hours after surgery (units of RSS, Ramsay Sedation Scale from 1 = Anxious or agitated or restless to 6 = Unresponsive) (MD, 95% CI) · adults having abdominal surgery

1 finding from 1 review

Perioperative dexmedetomidine for acute pain after abdominal surgery in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Very low

Intervention not reported

Postoperative nausea and vomiting (PONV) (RR, 95% CI) · adults having abdominal surgery

1 finding from 1 review

Perioperative dexmedetomidine for acute pain after abdominal surgery in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 217 participants
Low

Intervention not reported

Time to first passage of flatus (hours, MD, 95% CI) · adults having abdominal surgery

1 finding from 1 review

Perioperative dexmedetomidine for acute pain after abdominal surgery in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 77 participants
Low

Intervention not reported

Time to first passage of stool (hours, MD, 95% CI) · adults having abdominal surgery

The review found no eligible studies for this question.

1 finding from 1 review

Perioperative dexmedetomidine for acute pain after abdominal surgery in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Time to first out‐of‐bed mobilization (hours, MD, 95% CI) · adults having abdominal surgery

1 finding from 1 review

Perioperative dexmedetomidine for acute pain after abdominal surgery in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 77 participants
Low