Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

502 questions · 511 findings · 20 reviews · Headline outcomes only

No studies found 76 · 14.9%GRADE not reported 169 · 33.1%Very low 107 · 20.9%Low 92 · 18%Moderate 46 · 9%High 21 · 4.1%

A combination of individual‐level interventions vs no intervention/wait list/placebo/no stress‐reduction intervention

Stress symptoms ( · healthcare workers
3 findings from 1 review

Pharmacological interventions vs placebo

Depression: meeting study criteria for depression at end of · people with depression after stroke

It is very uncertain whether pharmacological interventions changes depression: meeting study criteria for depression at end of… compared with placebo (very low certainty).

2 findings from 1 review

Pharmacological interventions vs placebo

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes depression: < 50% reduction in scale scores at end of treatment… compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: death (secondary outcome) compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Adverse effects (central nervous system) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: all ‐ central nervous system events (e.g. confusion,… compared with placebo (very low certainty).

1 finding from 1 review