Findings

What do systematic reviews say?

15 questions · 15 findings · 4 reviews · Neuromuscular · Headline outcomes only

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No studies found 5 · 33.3%GRADE not reported 0 · 0%Very low 3 · 20%Low 2 · 13.3%Moderate 4 · 26.7%High 1 · 6.7%

Dextromethorphan and quinidine sulfate combination (DMQ) vs placebo

Reduction in the amount of saliva production in the short term using an objective measure · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

1 finding from 1 review

Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Very low

Dextromethorphan and quinidine sulfate combination (DMQ) vs placebo

Quality of life · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dextromethorphan and quinidine sulfate combination (DMQ) vs placebo

Adverse events · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

1 finding from 1 review

Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Moderate

Dextromethorphan and quinidine sulfate combination (DMQ) vs placebo

Participant‐reported improvement in sialorrhea in the short term · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

1 finding from 1 review

Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Moderate

Any CNTF vs placebo

Muscle strength · patients with the treatment of amyotrophic lateral sclerosis or motor neuron disease

1 finding from 1 review

Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis or motor neuron disease 2004 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1300 participants
High

Cough augmentation therapy vs an alternative cough augmentation technique or combination of techniques

Number of unscheduled hospital admissions for 'maintenance therapy' · participants with chronic neuromuscular diseases

The review found no eligible studies for this question.

1 finding from 1 review

Cough augmentation techniques for people with chronic neuromuscular disorders 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cough augmentation therapy vs an alternative cough augmentation technique or combination of techniques

Duration of hospital stay (days) for 'rescue' therapy · participants with chronic neuromuscular diseases

The review found no eligible studies for this question.

1 finding from 1 review

Cough augmentation techniques for people with chronic neuromuscular disorders 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cough augmentation therapy vs an alternative cough augmentation technique or combination of techniques

PCF · participants with chronic neuromuscular diseases

1 finding from 1 review

Cough augmentation techniques for people with chronic neuromuscular disorders 2021 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 198 participants
Very low

Cough augmentation therapy vs an alternative cough augmentation technique or combination of techniques

Any adverse events · participants with chronic neuromuscular diseases

1 finding from 1 review

Cough augmentation techniques for people with chronic neuromuscular disorders 2021 · Cochrane Headline outcomes only
no estimate extracted
64 participants
Very low

Cough augmentation therapy vs an alternative cough augmentation technique or combination of techniques

Quality of life for 'maintenance' therapy · participants with chronic neuromuscular diseases

The review found no eligible studies for this question.

1 finding from 1 review

Cough augmentation techniques for people with chronic neuromuscular disorders 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cough augmentation therapy vs an alternative cough augmentation technique or combination of techniques

Participant preference or satisfaction for 'rescue' and 'maintenance' therapy · participants with chronic neuromuscular diseases

The review found no eligible studies for this question.

1 finding from 1 review

Cough augmentation techniques for people with chronic neuromuscular disorders 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Quinine vs a quinine‐vitamin E combination (Q‐Vel)

Cramp intensity (on 3‐point scale; 1 = mild; 2 = moderate; 3 = severe) · patients with muscle cramps

1 finding from 1 review

Quinine for muscle cramps 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 510 participants
Low

Quinine vs a quinine‐vitamin E combination (Q‐Vel)

Major adverse events · patients with muscle cramps

1 finding from 1 review

Quinine for muscle cramps 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 510 participants
Moderate

Quinine vs a quinine‐vitamin E combination (Q‐Vel)

Minor adverse events · patients with muscle cramps

1 finding from 1 review

Quinine for muscle cramps 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 510 participants
Moderate

Quinine vs a quinine‐vitamin E combination (Q‐Vel)

Number of cramps over 2 weeks · patients with muscle cramps

1 finding from 1 review

Quinine for muscle cramps 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 486 participants
Low