Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

16 questions · 16 findings · 4 reviews

No studies found 1 · 6.3%GRADE not reported 0 · 0%Very low 1 · 6.3%Low 4 · 25%Moderate 10 · 62.5%High 0 · 0%

Clopidogrel vs placebo

Number of related surgical or radiological interventions · people with ESRD receiving haemodialysis through an arteriovenous fistula

Clopidogrel showed no clear difference in number of related surgical or radiological interventions (42 days) compared with placebo (moderate certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

Cardiovascular mortality · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin showed no clear difference in cardiovascular mortality compared with aspirin alone (moderate certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

All‐cause mortality · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin showed no clear difference in all‐cause mortality compared with aspirin alone (low certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

Fatal or nonfatal myocardial infarction · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin probably leads to lower fatal and non‐fatal myocardial infarction compared with aspirin alone (moderate certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

Fatal and non‐fatal ischaemic stroke · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin probably leads to lower fatal and non‐fatal ischaemic stroke compared with aspirin alone (moderate certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

Major bleeding · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin probably leads to higher major bleeding compared with aspirin alone (moderate certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

Minor bleeding · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin probably leads to higher minor bleeding compared with aspirin alone (moderate certainty).

1 finding from 1 review

Intervention not reported

Stroke (fatal and non‐fatal) (a. ticlopidine vs aspirin) (b. clopidogrel vs aspirin & dipyramidole) · patients with type 2 diabetes mellitus

The intervention probably leads to lower stroke (fatal and non‐fatal) (a. ticlopidine vs aspirin) (b.… (moderate certainty).

1 finding from 1 review