Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

202 questions · 247 findings · 34 reviews

No studies found 46 · 18.6%GRADE not reported 26 · 10.5%Very low 36 · 14.6%Low 56 · 22.7%Moderate 58 · 23.5%High 25 · 10.1%

Cerebral palsy (oral health status) vs Healthy controls

Oral health status (caries, gingivitis, calculus, treatment indices) · Children with cerebral palsy in Dubai

One study found children with cerebral palsy had caries and gingivitis similar to matched controls but more calculus and anomalies, with lower restorative care despite greater need (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Death or cerebral palsy · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in death or cerebral palsy (up to school age)** compared with placebo (outcomes (low certainty).

2 findings from 1 review

Magnesium sulphate vs placebo (outcomes

Cerebral palsy · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate leads to lower cerebral palsy (up to 2 years' corrected age)** compared with placebo (outcomes (high certainty).

2 findings from 1 review

Summary of findings table ‐ Silicone earplugs vs no earplugs

Cerebral palsy · preterm or very low birth weight infants

It is very uncertain whether summary of findings table ‐ Silicone earplugs changes cerebral palsy at 18 to 22 months' corrected age compared with no earplugs (very low certainty).

1 finding from 1 review

Individual tailored vs continuous tapered dexamethasone regimen

Death or cerebral palsy at 1 to 3 years · preterm infants at risk for bronchopulmonary dysplasia

Individual tailored showed no clear difference in death or cerebral palsy at 1 to 3 years compared with continuous tapered dexamethasone regimen (moderate certainty).

1 finding from 1 review

Lower vs higher cumulative dose dexamethasone regimen

Death or cerebral palsy at 1 to 3 years · preterm infants at risk for bronchopulmonary dysplasia

Lower showed no clear difference in death or cerebral palsy at 1 to 3 years compared with higher cumulative dose dexamethasone regimen (low certainty).

1 finding from 1 review

Later vs earlier initiation of dexamethasone therapy

Death or cerebral palsy at 1 to 3 years · preterm infants at risk for bronchopulmonary dysplasia

Later showed no clear difference in death or cerebral palsy at 1 to 3 years compared with earlier initiation of dexamethasone therapy (low certainty).

1 finding from 1 review

Dextrose gel vs placebo

Major neurological disability at 2 years of age (Defined as any of the following: legal blindness, sensorineural deafness requiring hearing aids, moderate or severe cerebral palsy or developmental delay/intellectual impairment (developmental quoti... · newborn infants at risk of neonatal hypoglycaemia

Dextrose gel showed no clear difference in major neurological disability at 2 years of age (Defined as any of… compared with placebo (low certainty).

1 finding from 1 review

Dextrose gel vs control

Major neurological disability at 2 years of age (Defined as any of the following: legal blindness, sensorineural deafness requiring hearing aids, moderate or severe cerebral palsy or developmental delay/intellectual impairment (developmental quoti... · newborn infants with hypoglycaemia

Oral dextrose gel showed no clear difference in major neurological disability at age 2 years or olderb Defined as… compared with control (low certainty).

1 finding from 1 review