Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

46 questions · 48 findings · 7 reviews · Hypertension

No studies found 1 · 2.1%GRADE not reported 0 · 0%Very low 2 · 4.2%Low 14 · 29.2%Moderate 27 · 56.3%High 4 · 8.3%

Antihypertensive drug class vs placebo

Calcium channel blocker (any dose) Mean duration of 3 weeks · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
2 findings from 1 review

First‐line thiazides vs calcium channel blockers

Adverse effects (side effects; treatment withdrawals) · patients with hypertension

First‐line thiazides may leads to lower withdrawals due to adverse effects Duration: 1 to 5 years compared with first‐line calcium channel blockers (low certainty).

1 finding from 1 review