Number of participants who experienced side effects related to use of bisphosphonates · Paget's disease of bone
Bisphosphonates showed no clear difference in number of participants who experienced side effects related to use… compared with placebo (low certainty).
1 finding from 1 review
Number of participants with change in bone pain (disappearance of pain)¹assessed on VAS · Paget's disease of bone
Bisphosphonates probably leads to higher number of participants with change in bone pain (disappearance of… compared with placebo (moderate certainty).
1 finding from 1 review
Number of participants who experienced radiologically‐confirmed fractures · Paget's disease of bone
It is very uncertain whether bisphosphonates changes number of participants who experienced radiologically‐confirmed… compared with placebo (very low certainty).
1 finding from 1 review
Number of participants who needed orthopaedic surgery (not measured) · Paget's disease of bone
1 finding from 1 review
Number of participants with change in quality of life measures (not measured) · Paget's disease of bone
1 finding from 1 review
Number of participants with change in hearing thresholds (not measured) · Paget's disease of bone
1 finding from 1 review
Withdrawals due to adverse events · Paget's disease of bone
Bisphosphonates showed no clear difference in number of participants who withdrew due to adverse events compared with placebo (low certainty).
1 finding from 1 review
Incident vertebral fractures Radiographic · adults with GIOP
Bisphosphonates leads to lower incident vertebral fractures Radiographic compared with control (high certainty).
1 finding from 1 review
Incident nonvertebral fractures Radiographic · adults with GIOP
Bisphosphonates showed no clear difference in incident nonvertebral fractures Radiographic compared with control (low certainty).
1 finding from 1 review
Lumbar spine bone mineral density (BMD) · adults with GIOP
1 finding from 1 review
Femoral neck bone mineral density (FN-BMD) · adults with GIOP
1 finding from 1 review
Serious adverse events · adults with GIOP
Bisphosphonates showed no clear difference in serious adverse events compared with control (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · adults with GIOP
Bisphosphonates showed no clear difference in withdrawals due to adverse events compared with control (low certainty).
1 finding from 1 review
Quality of life · adults with GIOP
1 finding from 1 review
Number of participants who experienced side effects related to use of bisphosphonates · Paget's disease of bone
Zoledronate showed no clear difference in number of participants who experienced side effects related to use… compared with pamidronate or risedronate (low certainty).
1 finding from 1 review
Number of participants who needed orthopaedic surgery (not measured) · Paget's disease of bone
1 finding from 1 review
Number of participants with change in quality of life measures (not measured) · Paget's disease of bone
1 finding from 1 review
Number of participants with change in hearing thresholds (not measured) · Paget's disease of bone
1 finding from 1 review
Withdrawals due to adverse events · Paget's disease of bone
It is very uncertain whether zoledronate changes number of participants who withdrew due to adverse events… compared with pamidronate or risedronate (very low certainty).
1 finding from 1 review
Number of participants with change in bone pain¹ assessed on VAS. · Paget's disease of bone
It is very uncertain whether zoledronate changes number of participants with change in bone pain¹ assessed on VAS. compared with pamidronate or risedronate (very low certainty).
1 finding from 1 review