Adverse effects: 1. Sedation · psychosis‐induced aggression or agitation
Benzodiazepines may leads to lower tranquillisation or asleep: sedation ‐ medium term ‐ lorazepam vs… compared with antihistamines plus antipsychotics (low certainty).
1 finding from 1 review
Global state: no improvement ‐ medium termAs defined in each study · psychosis‐induced aggression or agitation
Benzodiazepines + antipsychotics showed no clear difference in global state: no improvement ‐ lorazepam + risperidone vs lorazepam… compared with same enzodiazepines (low certainty).
1 finding from 1 review
Catatonia: clinically important change in catatonia symptoms (improved at least 50% on the VAS) · catatonia in people with schizophrenia or SMI
It is very uncertain whether lorazepam changes catatonia: clinically important change in catatonia symptoms… compared with oxazepam (very low certainty).
1 finding from 1 review
Duration of hospital stay (days) for 'rescue' therapy · catatonia in people with schizophrenia or SMI
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Satisfaction with care: clinically important change in satisfaction by informal care‐givers · catatonia in people with schizophrenia or SMI
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Satisfaction with care: clinically important change in satisfaction by recipients of care · catatonia in people with schizophrenia or SMI
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Global state: clinically important change in global state · catatonia in people with schizophrenia or SMI
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects: clinically important adverse effectsassessed by: number of participants with a delayed memory deficitStudy duration: 4 weeks · catatonia in people with schizophrenia or SMI
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
General functioning: clinically important change in specific aspects of functioning, such as life skills ‒ as defined by each of the studies · catatonia in people with schizophrenia or SMI
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Tranquil or asleep: Not tranquil or asleep ‐ by 30 mins · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE leads to lower tranquil or asleep: Not tranquil or asleep ‐ by 30 mins compared with BENZODIAZEPINES ‐ LORAZEPAM (high certainty).
1 finding from 1 review
Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion ‐ by 12 hours compared with BENZODIAZEPINES ‐ LORAZEPAM (moderate certainty).
1 finding from 1 review
Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation · people with psychosis‐induced aggression
1 finding from 1 review
Adverse effect: Specific ‐ Death · people with psychosis‐induced aggression
1 finding from 1 review
Service outcomes: Not discharged ‐ by 4 hours · people with psychosis‐induced aggression
HALOPERIDOL + PROMETHAZINE showed no clear difference in service outcomes: Not discharged ‐ by 4 hours compared with BENZODIAZEPINES ‐ LORAZEPAM (high certainty).
1 finding from 1 review
Aggression · people with psychosis‐induced aggression
1 finding from 1 review
Economic outcomes: Cost of care · people with psychosis‐induced aggression
1 finding from 1 review