Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 23 findings · 2 reviews

No studies found 4 · 17.4%GRADE not reported 0 · 0%Very low 11 · 47.8%Low 3 · 13%Moderate 5 · 21.7%High 0 · 0%

Any antihypertensive drug vs no antihypertensive drugs/placebo

Changed/stopped drugs due to maternal side‐effects · women with mild to moderate hypertension during pregnancy

Any antihypertensive drug showed no clear difference in changed/stopped drugs due to maternal side‐effects compared with no antihypertensive drugs/placebo (low certainty).

1 finding from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Maternal · women with mild to moderate hypertension during pregnancy

The review found no eligible studies for this question.

2 findings from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Elective delivery (induction of labour + elective caesarean section) · women with mild to moderate hypertension during pregnancy

Any antihypertensive drug showed no clear difference in elective delivery (induction of labour + elective caesarean section) compared with no antihypertensive drugs/placebo (moderate certainty).

1 finding from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Fetal/neonatal/infant · women with mild to moderate hypertension during pregnancy

The review found no eligible studies for this question.

2 findings from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Admission to neonatal or intensive care nursery · women with mild to moderate hypertension during pregnancy

Any antihypertensive drug showed no clear difference in admission to neonatal or intensive care nursery compared with no antihypertensive drugs/placebo (low certainty).

1 finding from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Total reported fetal or neonatal deaths (including miscarriage) · women with mild to moderate hypertension during pregnancy

Any antihypertensive drug showed no clear difference in total reported fetal or neonatal deaths (including miscarriage) compared with no antihypertensive drugs/placebo (moderate certainty).

1 finding from 1 review

Any antihypertensive drug vs no antihypertensive drugs/placebo

Small‐for‐gestational age · women with mild to moderate hypertension during pregnancy

Any antihypertensive drug showed no clear difference in small‐for‐gestational age compared with no antihypertensive drugs/placebo (moderate certainty).

1 finding from 1 review

Antihypertensive drug class vs placebo

Angiotensin receptor blocker (any dose) Mean duration of 4 weeks · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
2 findings from 1 review

Antihypertensive drug class vs placebo

Beta‐blocker (any dose) Mean duration of 4 weeks · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
2 findings from 1 review

Antihypertensive drug class vs placebo

Calcium channel blocker (any dose) Mean duration of 3 weeks · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
2 findings from 1 review

Antihypertensive drug class vs placebo

Beta‐blocker/thiazide combination (any dose) Mean duration of 10 weeks · children (from 1 to 18 years of age) with hypertension from primary or secondary causes
2 findings from 1 review