Microbial reduction (viable count, log CFU/mL) · Patients with dental caries (in vivo cariogenic microorganisms, including children with early childhood caries)
In randomized clinical trials, photodynamic therapy significantly reduced cariogenic microbial counts versus untreated control (SMD -1.16, 95% CI -2.02 to -0.30; 2 trials), but heterogeneity was high (I2=70%) and considered too high to rely on; certainty was not graded.
1 finding from 1 review
Microbial reduction (viable count, log CFU/mL) · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro
In in vitro studies, photodynamic therapy significantly reduced cariogenic microbial counts versus untreated control (SMD -2.64, 95% CI -4.50 to -0.79; 2 studies; I2=0%); certainty was not graded.
1 finding from 1 review
Any adverse effect related to aPDT · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Any adverse effect related to aPDT · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
1 finding from 1 review
Risk with control: 23 studies reported that no adverse effects of aPDT were observed. Number of participants (studies): 639 (24 studies). Certainty: Moderate. (24 studies reported adverse effects, with all studies…
24 studies · 639 participants
Moderate
Any adverse effect related to aPDT · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care
1 finding from 1 review
Risk with control: In 1 study, 1 participant had an abscess (not specified if this was related to aPDT). In 2 other studies, no adverse effects of aPDT were observed. Number of participants (studies): 134 (3 RCTs).…
3 studies · 134 participants
Moderate
Quality of life · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Change in gingival recession (REC) · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT
Outcome not reported · Adults (> 18 years) with peri-implant mucositis, receiving supportive treatment
The review found no eligible studies for this question.
1 finding from 1 review
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT
Outcome not reported · Adults (> 18 years) with peri-implantitis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Change in probing pocket depth (PPD) · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… showed no clear difference in change in probing depth (PD/PPD) compared with submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT; GRADE not reported.
1 finding from 1 review
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT
Outcome not reported · Adults (> 18 years) with peri-implantitis, receiving supportive treatment
The review found no eligible studies for this question.
1 finding from 1 review
Patient satisfaction · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Pocket closure · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Attachment change · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Change in bleeding on probing (BOP) · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… led to higher change in bleeding on probing (BOP) compared with submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT; GRADE not reported.
1 finding from 1 review
Pocket closure · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
2 findings from 1 review
Three studies evaluated the proportion of closed pockets three months after treatment (Al-Zahrani 2011; Courval 2020; Rodrigues 2023); studies used different criteria to measure this outcome. All studies reported an…
3 studies
GRADE not reported
No studies measured this outcome at 6 months (SoF row labeled 'Change in pocket depth from baseline to 6 months after initial treatment').
Studies not reported
No studies found
Patient satisfaction · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
The review found no eligible studies for this question.
1 finding from 1 review
Change in probing pocket depth (PPD) · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… led to higher change in probing pocket depth (PPD) compared with subgingival instrumentation (SI) alone (hand or power-driven, or…; GRADE not reported.
2 findings from 1 review
Attachment change · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… led to higher change in clinical attachment level (CAL) compared with subgingival instrumentation (SI) alone (hand or power-driven, or…; GRADE not reported.
2 findings from 1 review
Attachment change · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care
It is very uncertain whether adjunctive antimicrobial photodynamic therapy (aPDT) applied after… changes change in clinical attachment level (CAL) compared with subgingival instrumentation (SI) alone (hand or power-driven, or… (very low certainty).
2 findings from 1 review