Findings

What do systematic reviews say?

406 questions · 416 findings · 20 reviews · Common Mental Disorders

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No studies found 73 · 17.5%GRADE not reported 9 · 2.2%Very low 144 · 34.6%Low 123 · 29.6%Moderate 59 · 14.2%High 8 · 1.9%

Antidepressants vs placebo

Outcomes (2‐6 months post‐treatment) · adults with panic disorder

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

Antidepressants may leads to lower failure to respond compared with placebo (low certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.72 [0.66, 0.79]
30 studies · 6500 participants
Low

Antidepressants vs placebo

Leaving the study early · adults with panic disorder

Antidepressants probably leads to lower total number of dropouts compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.88 [0.81, 0.97]
38 studies · 7850 participants
Moderate

Antidepressants vs placebo

Failure to remit at endpoint · adults with panic disorder

Antidepressants probably leads to lower failure to remit compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 0.83 [0.78, 0.88]
24 studies · 6164 participants
Moderate

Antidepressants vs placebo

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 3699 participants
Low
Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 2010 participants
Low

Antidepressants vs placebo

Withdrawals due to adverse events · adults with panic disorder

Antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.49 [1.25, 1.78]
33 studies · 7688 participants
Moderate

Antidepressants vs benzodiazepines

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

Antidepressants showed no clear difference in failure to respond compared with benzodiazepines (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.99 [0.67, 1.47]
2 studies · 215 participants
Low

Antidepressants vs benzodiazepines

Leaving the study early · adults with panic disorder

It is very uncertain whether antidepressants changes total number of dropouts compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.64 [1.03, 2.63]
7 studies · 1449 participants
Very low

Antidepressants vs benzodiazepines

Failure to remit at endpoint · adults with panic disorder

Antidepressants probably leads to higher failure to remit compared with benzodiazepines (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.18 [1.01, 1.37]
3 studies · 1002 participants
Moderate

Antidepressants vs benzodiazepines

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1144 participants
Very low
Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Antidepressants vs benzodiazepines

Withdrawals due to adverse events · adults with panic disorder

Antidepressants may leads to higher number of dropouts due to adverse effects compared with benzodiazepines (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.72 [1.03, 2.87]
3 studies · 1002 participants
Low

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity ‐ mean EPDS score (early phase, < 5 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 598 participants
Moderate

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity (acute phase, 5 ≤ 12 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 347 participants
Low

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity: continuous phase (> 12 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Antidepressants plus benzodiazepines vs antidepressants alone

Acceptability ‐ total dropouts · patients with major depression

Antidepressants plus benzodiazepines showed no clear difference in acceptability of treatment (dropout for any reason) compared with antidepressants alone (moderate certainty).

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
RR 0.76 [0.54, 1.07]
10 studies · 731 participants
Moderate

Antidepressants plus benzodiazepines vs antidepressants alone

Anxiety · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 129 participants
Very low

Antidepressants plus benzodiazepines vs antidepressants alone

Adverse effects (dropouts) · patients with major depression

Antidepressants plus benzodiazepines probably leads to lower adverse effects (dropouts) compared with antidepressants alone (moderate certainty).

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
RR 0.54 [0.32, 0.9]
10 studies · 731 participants
Moderate

Antidepressants vs placebo

Gambling symptom severity · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 225 participants
Very low

Antidepressants vs placebo

Gambling expenditure · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 144 participants
Low

Antidepressants vs placebo

Gambling frequency ‐ not measured · treatment of disordered and problem gambling

1 finding from 1 review

Pharmacological interventions for the treatment of disordered and problem gambling 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low