What do systematic reviews say?

Summary of findings ‐ Intranasal lorazepam vs intramuscular paraldehyde

Summary of findings ‐ Intranasal lorazepam may leads to lower additional drugs required to terminate the seizure: 2 or more… compared with intramuscular paraldehyde (low certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.38 [0.18, 0.81]
  1 study · 160 participants
  Low

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam

Lorazepam IV probably leads to lower non‐cessation of seizures compared with diazepam IV (moderate certainty).

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  RR 0.64 [0.45, 0.9]
  3 studies · 264 participants
  Moderate

Diazepam gel vs Placebo gel

Diazepam gel probably leads to lower non‐cessation of seizures compared with placebo gel (moderate certainty).

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  RR 0.43 [0.3, 0.62]
  2 studies · 165 participants
  Moderate

Diazepam gel vs Placebo gel

Diazepam gel showed no clear difference in adverse effects compared with placebo gel (moderate certainty).

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  RR 1.5 [0.94, 2.37]
  2 studies · 165 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam

Lorazepam IV showed no clear difference in requirement for ventilatory support compared with diazepam IV (low certainty).

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  RR 0.73 [0.36, 1.49]
  3 studies · 264 participants
  Low

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 264 participants
  Very low

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam

Lorazepam IV probably leads to lower continuation of status requiring a different drug or general… compared with diazepam IV (moderate certainty).

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  RR 0.63 [0.45, 0.88]
  3 studies · 264 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 203 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Lorazepam IV showed no clear difference in non‐cessation of seizures compared with diazepam plus phenytoin IV (low certainty).

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 370 participants
  Low

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Lorazepam IV showed no clear difference in adverse effects compared with diazepam plus phenytoin IV (moderate certainty).

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  RR 0.85 [0.63, 1.15]
  2 studies · 370 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 178 participants
  GRADE not reported

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

• Anticonvulsant therapy for status epilepticus 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 178 participants
  GRADE not reported