Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

48 questions · 48 findings · 7 reviews · Pregnancy and Childbirth · Headline outcomes only

No studies found 3 · 6.3%GRADE not reported 10 · 20.8%Very low 13 · 27.1%Low 10 · 20.8%Moderate 8 · 16.7%High 4 · 8.3%

Antibiotic prophylaxis vs no treatment or placebo

Adverse effects of antibiotics (skin rash) · Women who had normal vaginal births

It is very uncertain whether routine antibiotic prophylaxis changes adverse effects of antibiotics (skin rash) compared with no treatment or placebo (very low certainty).

1 finding from 1 review

Antibiotic prophylaxis vs no treatment

Incidence of episiotomy wound dehiscence without wound infection · women with episiotomy repair following vaginal birth

It is very uncertain whether antibiotic prophylaxis changes incidence of episiotomy wound dehiscence without wound infection compared with no treatment (very low certainty).

1 finding from 1 review

Antibiotic prophylaxis vs no treatment

Infection rate at 2 weeks postpartum ‐ perineal wound infection in third‐ or fourth‐degree tear · Women with third‐ and fourth‐degree perineal tear during vaginal birth

Antibiotic prophylaxis probably leads to lower infection rate at 2 weeks postpartum ‐ perineal wound infection in… compared with no treatment (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis vs no treatment

Infection rate at 6 weeks postpartum ‐ perineal wound infection in third‐ or fourth‐degree tear · Women with third‐ and fourth‐degree perineal tear during vaginal birth

Antibiotic prophylaxis showed no clear difference in infection rate at 6 weeks postpartum ‐ perineal wound infection in… compared with no treatment (low certainty).

1 finding from 1 review

Antibiotic prophylaxis vs no treatment or placebo

Wound infection (episiotomy dehiscence) · Women who had normal vaginal births

It is very uncertain whether routine antibiotic prophylaxis changes wound infection (episiotomy dehiscence) compared with no treatment or placebo (very low certainty).

1 finding from 1 review