Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

45 questions · 56 findings · 6 reviews · Vascular

No studies found 3 · 5.4%GRADE not reported 4 · 7.1%Very low 17 · 30.4%Low 19 · 33.9%Moderate 9 · 16.1%High 4 · 7.1%

Angioplasty vs primary stenting

Improvement in the stage of PAD according to Rutherford's criteria (one year) · patients with symptomatic Iliac artery lesions

Angioplasty showed no clear difference in improvement in the stage of PAD according to Rutherford's criteria… compared with primary stenting (low certainty).

1 finding from 1 review

Angioplasty vs primary stenting

Resolution of symptoms and signs (one year) · patients with symptomatic Iliac artery lesions

Angioplasty showed no clear difference in resolution of symptoms and signs (one year) compared with primary stenting (low certainty).

1 finding from 1 review

Drug‐eluting balloon angioplasty at 6 months vs uncoated balloon angioplasty at 6 months

Target lesion revascularization · patients with in‐stent restenosis of the femoropopliteal arteries

It is very uncertain whether drug‐eluting balloon angioplasty at 6 months changes target lesion revascularization (TLR) compared with uncoated balloon angioplasty at 6 months (very low certainty).

1 finding from 1 review

Drug‐eluting balloon angioplasty at 6 months vs uncoated balloon angioplasty at 6 months

Binary restenosis · patients with in‐stent restenosis of the femoropopliteal arteries

It is very uncertain whether drug‐eluting balloon angioplasty at 6 months changes binary restenosis compared with uncoated balloon angioplasty at 6 months (very low certainty).

1 finding from 1 review

Drug‐eluting balloon angioplasty at 6 months vs uncoated balloon angioplasty at 6 months

Death · patients with in‐stent restenosis of the femoropopliteal arteries

It is very uncertain whether drug‐eluting balloon angioplasty at 6 months changes death compared with uncoated balloon angioplasty at 6 months (very low certainty).

1 finding from 1 review

Drug‐eluting balloon angioplasty at 6 months vs uncoated balloon angioplasty at 6 months

Improvement ≥ 1 Rutherford category · patients with in‐stent restenosis of the femoropopliteal arteries

It is very uncertain whether drug‐eluting balloon angioplasty at 6 months changes improvement ≥ 1 Rutherford category compared with uncoated balloon angioplasty at 6 months (very low certainty).

1 finding from 1 review

Subintimal angioplasty with stenting vs remote endarterectomy

Clinical improvement: Rutherford classification improvement Rutherford classification · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in clinical improvement: Rutherford classification improvement… compared with remote endarterectomy (low certainty).

1 finding from 1 review

Subintimal angioplasty with stenting vs remote endarterectomy

Clinical improvement: ABI improvement Significant postexercise ABI improvement · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in clinical improvement: ABI improvement Significant postexercise ABI… compared with remote endarterectomy (low certainty).

1 finding from 1 review

Subintimal angioplasty with stenting vs remote endarterectomy

months' patency rate · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in months' patency rate compared with remote endarterectomy (low certainty).

3 findings from 1 review

Drug‐eluting balloon vs uncoated balloon angioplasty at 12 months

Amputation · people with peripheral arterial disease of the lower limbs

Drug‐eluting balloon showed no clear difference in amputation compared with uncoated balloon angioplasty at 12 months (high certainty).

1 finding from 1 review

Drug‐eluting balloon vs uncoated balloon angioplasty at 12 months

Primary vessel patency · people with peripheral arterial disease of the lower limbs

Drug‐eluting balloon leads to higher primary vessel patency compared with uncoated balloon angioplasty at 12 months (high certainty).

1 finding from 1 review