Survival to hospital discharge · participants with bradyasystolic cardiac arrest in adults
Aminophylline showed no clear difference in survival to hospital discharge compared with placebo (moderate certainty).
2 findings from 1 review
Return of spontaneous circulation · participants with bradyasystolic cardiac arrest in adults
Aminophylline showed no clear difference in return of spontaneous circulation compared with placebo (high certainty).
2 findings from 1 review
Early administration of aminophylline: survival to hospital admission · participants with bradyasystolic cardiac arrest in adults
Aminophylline showed no clear difference in survival to admission compared with placebo (moderate certainty).
2 findings from 1 review
PEF (L/min) · patients with adults with acute asthma
Aminophylline showed no clear difference in PEF (L/min) ‐ at 60 min compared with placebo (low certainty).
1 finding from 1 review
Hospital admissions · patients with adults with acute asthma
Aminophylline showed no clear difference in hospital admissions compared with placebo (moderate certainty).
1 finding from 1 review
Tremor · patients with adults with acute asthma
Aminophylline showed no clear difference in tremor compared with placebo (low certainty).
1 finding from 1 review
Vomiting · patients with adults with acute asthma
Aminophylline probably leads to higher vomiting compared with placebo (moderate certainty).
1 finding from 1 review
Arrhythmia/palpitations · patients with adults with acute asthma
Aminophylline probably leads to higher arrhythmia/palpitations compared with placebo (moderate certainty).
1 finding from 1 review
Convulsions · patients with adults with acute asthma
1 finding from 1 review
Length of hospital stay · patients with acute asthma
1 finding from 1 review
PEF (L/min) · patients with acute asthma
1 finding from 1 review
FEV1 (L) · patients with acute asthma
1 finding from 1 review
Heart rate · patients with acute asthma
1 finding from 1 review
Clinical failure4 · patients with acute asthma
1 finding from 1 review
Failed apnea reduction · treatment of apnea
Doxapram showed no clear difference in 1a. Failed apnea reduction after 2–7 days – doxapram compared to no… compared with no treatment, placebo, methylxanthine (including theophylline,… (low certainty).
3 findings from 1 review
RR 0.45 [0.2, 1.05]
1 study · 21 participants
Low
RR 1.35 [0.53, 3.45]
4 studies · 84 participants
Very low
RR 0.08 [0.01, 1.17]
1 study · 10 participants
Very low
4a.Death at any time during initial hospitalization – doxapram compared to no treatment for the treatment of apnea · treatment of apnea
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
4b. Death at any time during initial hospitalization – doxapram compared to alternative treatment for the treatment of apnea · treatment of apnea
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
5a. Moderate‐to‐severe neurodevelopmental disability or intellectual impairment after 2 years of age – doxapram compared to no treatment for the treatment of apnea · treatment of apnea
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
5b. Moderate‐to‐severe neurodevelopmental disability or intellectual impairment after 2 years of age – doxapram compared to alternative treatment for the treatment of apnea · treatment of apnea
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
5c. Moderate‐to‐severe neurodevelopmental disability or intellectual impairment after 2 years of age – doxapram as an adjunct to methylxanthine compared to methylxanthine alone for the treatment of apnea · treatment of apnea
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found