Cochrane · systematic review · CD002742
Addition of intravenous aminophylline to inhaled beta₂‐agonists in adults with acute asthma
Nair, P, Milan, SJ, Rowe, BH · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 33.3%Moderate 4 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Aminophylline compared to Placebo for adults with acute asthma
Population: patients with adults with acute asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PEF (L/min) ‐ at 60 min Aminophylline vs Placebo | MD 6.24 | 6 studies · 302 participants | Low Downgraded: risk of bias, inconsistency |
Hospital admissions Aminophylline vs Placebo | OR 0.58 [0.3, 1.12] | 6 studies · 315 participants | Moderate Downgraded: risk of bias, inconsistency |
Tremor Aminophylline vs Placebo | OR 2.6 [0.62, 11.02] | 5 studies · 249 participants | Low Downgraded: risk of bias, inconsistency |
Vomiting Aminophylline vs Placebo | OR 4.21 [2.2, 8.07] | 7 studies · 321 participants | Moderate Downgraded: risk of bias, inconsistency |
Arrhythmia/palpitations Aminophylline vs Placebo | OR 3.02 [1.15, 7.9] | 6 studies · 249 participants | Moderate Downgraded: risk of bias, inconsistency |
Convulsions Aminophylline vs Placebo | no estimate extracted | 1 study · 21 participants | Moderate Downgraded: risk of bias, inconsistency |