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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 4 · 57.1%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

ASENAPINE vs placebo

Global state: No clinically important change (as defined by the original studies) · adults with schizophrenia

ASENAPINE may leads to lower global state: No clinically important change CGI‐I compared with PLACEBO (low certainty).

1 finding from 1 review

ASENAPINE vs placebo

Clinical response: no clinically significant response in mental state · adults with schizophrenia

It is very uncertain whether ASENAPINE changes mental state: No clinically important change PANSS compared with PLACEBO (very low certainty).

1 finding from 1 review

ASENAPINE vs placebo

Adverse effects: Incidence of serious adverse effects · adults with schizophrenia

It is very uncertain whether ASENAPINE changes adverse effects: Incidence of serious adverse effects compared with PLACEBO (very low certainty).

1 finding from 1 review

ASENAPINE vs placebo

Adverse effects: 1. Clinically significant extrapyramidal side effects (2‐10 weeks) vs. standard higher dose (> 7.5‐15 mg/day) · adults with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

ASENAPINE vs placebo

Leaving the study early · adults with schizophrenia

It is very uncertain whether ASENAPINE changes leaving the study early ‐ any reason compared with PLACEBO (very low certainty).

1 finding from 1 review