What do systematic reviews say?

Intervention not reported

• Surgical interventions for lamellar macular holes 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 34 participants
  Low

Intervention not reported

• Surgical interventions for lamellar macular holes 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 34 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Surgical interventions for lamellar macular holes 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Surgical interventions for lamellar macular holes 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

The review found no eligible studies for this question.

• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes
  Favourable position of the erupted PDC was not reported for this comparison.
  0 studies
  No studies found

Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

The review found no eligible studies for this question.

• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

The review found no eligible studies for this question.

• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes
  The study did not report cost-effectiveness.
  0 studies
  No studies found

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

The review found no eligible studies for this question.

• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

The review found no eligible studies for this question.

• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Clindamycin + SRP vs Metronidazole + SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Azithromycin + SRP vs SRP

Azithromycin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD -0.57 [-1.08, -0.07]
  6 studies · 216 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD -0.77 [-2.33, 0.79]
  2 studies · 110 participants
  Very low
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD -0.60 [-1.02, -0.18]
  7 studies · 258 participants
  GRADE not reported

Doxycycline + SRP vs Metronidazole + SRP

Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD 0.34 [-0.08, 0.76]
  3 studies · 75 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD 1.10 [0.36, 1.84]
  1 study · 27 participants
  Very low
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD -0.12 [-0.72, 0.49]
  2 studies · 49 participants
  GRADE not reported

Metronidazole + SRP vs SRP

It is very uncertain whether metronidazole + SRP changes probing pocket depth compared with SRP (very low certainty).

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD -1.11 [-2.84, 0.61]
  2 studies · 47 participants
  Very low
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD -0.59 [-0.95, -0.23]
  4 studies · 94 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD -0.10 [-0.37, 0.16]
  4 studies · 108 participants
  GRADE not reported

Doxycycline + SRP vs SRP

It is very uncertain whether doxycycline + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD -0.80 [-1.49, -0.11]
  1 study · 22 participants
  Very low
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD -0.61 [-1.14, -0.08]
  3 studies · 65 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD 0.15 [-0.53, 0.83]
  2 studies · 43 participants
  GRADE not reported

Azithromycin + SRP vs SRP

Azithromycin + SRP showed no clear difference in percentage of closed pockets compared with SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD -2.90 [-13.91, 8.11]
  1 study · 40 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD 2.50 [-10.19, 15.19]
  1 study · 40 participants
  Very low

Doxycycline + SRP vs SRP

Doxycycline + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD 0.10 [-0.29, 0.50]
  2 studies · 43 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD -1.00 [-1.78, -0.22]
  1 study · 22 participants
  Very low
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD -0.43 [-0.88, 0.01]
  3 studies · 65 participants
  GRADE not reported

Doxycycline + SRP vs Metronidazole + SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Summary of findings: Fibrin sealant vs Conventional (simple interrupted) suturing

Fibrin sealant led to higher trismus / maximum mouth opening (mean) compared with conventional suturing; GRADE not reported.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  7 days · fibrin sealant vs conventional
  MD 3.50 [2.69, 4.31]
  1 study · 30 participants
  GRADE not reported

Clindamycin + SRP vs Doxycycline + SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Amoxicillin + metronidazole + SRP vs SRP

Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Intermediate-term (> 3 months to < 1 year)
  MD -0.47 [-0.68, -0.26]
  6 studies · 215 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Short-term (≤ 3 months)
  MD -0.18 [-0.33, -0.04]
  15 studies · 562 participants
  GRADE not reported
• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  MD -0.30 [-0.42, -0.18]
  2 studies · 389 participants
  Very low