What do systematic reviews say?

Clindamycin vs penicillin plus chloramphenicol compared to for

• Antibiotics for treating septic abortion 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Moderate

Clindamycin vs penicillin plus chloramphenicol compared to for

Clindamycin showed no clear difference in complications compared with penicillin plus chloramphenicol compared to for (moderate certainty).

• Antibiotics for treating septic abortion 2016 · Cochrane Headline outcomes only
  RR 7.57 [0.98, 58.61]
  1 study · 77 participants
  Moderate

Penicillin plus chloramphenicol vs cephalothin plus kanamycin

• Antibiotics for treating septic abortion 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 56 participants
  Low

Penicillin plus chloramphenicol vs cephalothin plus kanamycin

• Antibiotics for treating septic abortion 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 56 participants
  Low

Tetracycline vs penicillin G

• Antibiotics for treating septic abortion 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Low

Intravenous vs irrigation (lavage)

Intravenous route showed no clear difference in endometritis compared with irrigation (lavage) (low certainty).

• Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section 2016 · Cochrane Headline outcomes only
  RR 0.95 [0.7, 1.29]
  8 studies · 966 participants
  Low

Intravenous vs irrigation (lavage)

It is very uncertain whether intravenous route changes wound infection compared with irrigation (lavage) (very low certainty).

• Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section 2016 · Cochrane Headline outcomes only
  RR 0.49 [0.17, 1.43]
  7 studies · 859 participants
  Very low

Intravenous vs irrigation (lavage)

It is very uncertain whether intravenous route changes postpartum febrile morbidity compared with irrigation (lavage) (very low certainty).

• Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section 2016 · Cochrane Headline outcomes only
  RR 0.87 [0.48, 1.6]
  3 studies · 264 participants
  Very low

Intravenous vs irrigation (lavage)

It is very uncertain whether intravenous route changes urinary tract infection compared with irrigation (lavage) (very low certainty).

• Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section 2016 · Cochrane Headline outcomes only
  RR 0.74 [0.25, 2.15]
  5 studies · 660 participants
  Very low

Intravenous vs irrigation (lavage)

• Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 81 participants
  Very low

Intravenous vs irrigation (lavage)

• Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 284 participants
  Very low

Intravenous vs irrigation (lavage)

The review found no eligible studies for this question.

• Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Clindamycin plus aminoglycoside vs other regimens

Clindamycin plus aminoglycoside may leads to lower treatment failure ‐ lincosamides versus cephalosporins compared with any other regimen (low certainty).

• Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
  RR 0.69 [0.49, 0.99]
  8 studies · 872 participants
  Low

Clindamycin plus aminoglycoside vs other regimens

Clindamycin plus aminoglycoside may leads to lower treatment failure ‐ lincosamides versus penicillins compared with any other regimen (low certainty).

• Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
  RR 0.65 [0.46, 0.9]
  7 studies · 689 participants
  Low

Clindamycin plus aminoglycoside vs other regimens

It is very uncertain whether clindamycin plus aminoglycoside changes severe complication ‐ lincosamides versus cephalosporins compared with any other regimen (very low certainty).

• Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
  RR 2.4 [0.3, 19.19]
  4 studies · 476 participants
  Very low

Clindamycin plus aminoglycoside vs other regimens

Clindamycin plus aminoglycoside showed no clear difference in severe complication ‐ lincosamides versus penicillins compared with any other regimen (low certainty).

• Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
  RR 0.33 [0.09, 1.18]
  5 studies · 422 participants
  Low

Clindamycin plus aminoglycoside vs other regimens

Clindamycin plus aminoglycoside may leads to lower wound infection ‐ lincosamides versus cephalosporins compared with any other regimen (low certainty).

• Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
  RR 0.53 [0.3, 0.93]
  4 studies · 500 participants
  Low
• Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
  RR 0.46 [0.21, 1]
  3 studies · 339 participants
  Low

Clindamycin plus aminoglycoside vs other regimens

Clindamycin plus aminoglycoside showed no clear difference in allergic reaction ‐ lincosamides versus cephalosporins compared with any other regimen (low certainty).

• Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
  RR 1.36 [0.44, 4.21]
  6 studies · 680 participants
  Low
• Antibiotic regimens for postpartum endometritis 2015 · Cochrane Headline outcomes only
  RR 1 [0.14, 6.96]
  2 studies · 247 participants
  Very low

Intervention not reported

The intervention probably leads to lower exacerbations Number of events (moderate certainty).

• Prolonged antibiotics for non‐cystic fibrosis bronchiectasis in children and adults 2015 · Cochrane Headline outcomes only
  OR 0.31 [0.12, 0.52]
  10 studies · 654 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in hospitalisations Number of events (moderate certainty).

• Prolonged antibiotics for non‐cystic fibrosis bronchiectasis in children and adults 2015 · Cochrane Headline outcomes only
  OR 0.4 [0.14, 1.11]
  7 studies · 643 participants
  Moderate