Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,890 questions · 3,917 findings · 272 reviews · All outcomes

No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Control: fluoride toothpaste alone, placebo mouthrinse + toothpaste, or non-fluoride (chlorhexidine) mouthrinse + toothpaste

Incidence of initial enamel caries / white spot lesions adjacent to bracket base (subject level, dichotomized) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)

Adding a fluoride mouthrinse to daily fluoride toothpaste produced a small reduction in the incidence of initial caries/white spot lesions adjacent to brackets (pooled risk difference -0.07, 95% CI -0.14 to -0.01; 5 studies, 491 subjects), but the authors judged the overall evidence inconclusive (ungraded).

1 finding from 1 review

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Control: fluoride toothpaste alone, placebo mouthrinse + toothpaste, or non-fluoride (chlorhexidine) mouthrinse + toothpaste

Side effects or other adverse events · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)

No adverse effects were reported in any of the seven included studies (ungraded).

1 finding from 1 review

Acidic bacillary pH on teeth vs Non-acidic bacillary pH

Dental caries · Primary school children in Ethiopia

Acidic bacillary pH on the teeth was associated with higher odds of dental caries (OR 2.42, 95% CI 1.494-3.335; ungraded).

1 finding from 1 review

Slum / urban-disadvantaged setting vs Non-slum urban / general-urban / national population

Ever utilised dental services · Adult residents of slums and non-slum urban settings of LMICs

Ever-use of dental services is low-to-moderate (17%-71%) and generally lower in slum/rural groups; ungraded.

1 finding from 1 review

Poor / no tooth brushing habit vs Good tooth brushing habit

Dental caries · Primary school children in Ethiopia

A poor tooth-cleaning habit was associated with higher odds of dental caries (OR 3.90, 95% CI 2.761-5.045; ungraded).

1 finding from 1 review

Cesarean section delivery vs Vaginal delivery

Early childhood caries (ECC) · Children aged <6 years

No significant association between cesarean vs vaginal delivery and ECC among America/Canada/Brazil studies (OR 1.11, 95% CI 0.70-1.76).

17 findings from 1 review
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Silver diamine fluoride (SDF) vs Sealants or resin infiltration

Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material

Dental pain or sensitivity · Children and adults (with or without carious lesions)

It is very uncertain whether silver diamine fluoride (SDF) changes dental pain or sensitivity compared with atraumatic restorative treatment (ART) with glass ionomer cement… (very low certainty).

1 finding from 1 review

SDF (given at a particular frequency, concentration, or duration) vs SDF (given at a different frequency, concentration, or duration)

Caries arrest · Children and adults (with or without carious lesions)
1 finding from 1 review

Slum / urban-disadvantaged setting vs Non-slum urban / general-urban / national population

Dental service utilisation within the past year · Adult residents of slums and non-slum urban settings of LMICs

Past-year dental service use varies widely (4%-72%); ungraded.

1 finding from 1 review

Slum / urban-disadvantaged setting vs Non-slum urban setting

Determinants of oral diseases · Adult residents of slums and non-slum urban settings of LMICs

Older age, lower education and income, poor oral hygiene, and disadvantaged residential setting were associated with oral diseases; directions varied across studies.

1 finding from 1 review