Intervention not reported
Dental caries in primary dentition (presence)
The intervention led to higher dental caries in primary dentition (presence); GRADE not reported.
1 finding from 1 review
Positive LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the positive lr of radiographic detection for all (initial and advanced) occlusal caries was 1.74 (95% CI 1.3 to 2.4) (ungraded).
3 findings from 1 review
Positive LR 1.74 [1.3, 2.4]
14 studies
GRADE not reported
Positive LR 2.36 [1.4, 4.1]
9 studies
GRADE not reported
Positive LR 2.02 [1.4, 2.9]
11 studies
GRADE not reported
Negative LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for all (initial and advanced) occlusal caries was 0.79 (95% CI 0.65 to 0.96) (ungraded).
3 findings from 1 review
Negative LR 0.79 [0.65, 0.96]
14 studies
GRADE not reported
Negative LR 0.76 [0.58, 0.99]
9 studies
GRADE not reported
Negative LR 0.75 [0.6, 0.94]
11 studies
GRADE not reported
Caries increment in permanent teeth · Children or adolescents
The NMR reported a difference between fluoride in gel and no treatment at every displayed randomisation year; no GRADE assessment was reported.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Sensitivity for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, pooled sensitivity of radiographic detection for advanced proximal caries was 44.4% (95% CI 38 to 51) (ungraded).
3 findings from 1 review
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Sensitivity 44.4 [38, 51]
22 studies
GRADE not reported
Positive LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the positive lr of visual detection for advanced occlusal caries was 7.09 (95% CI 5.6 to 8.9) (ungraded).
3 findings from 1 review
Positive LR 7.09 [5.6, 8.9]
94 studies
GRADE not reported
Positive LR 5.0 [4.3, 5.8]
55 studies
GRADE not reported
Positive LR 12.5 [9.2, 16.9]
50 studies
GRADE not reported
Caries increment in permanent teeth · Children or adolescents
The NMR reported a difference between fluoride in rinse and no treatment at every displayed randomisation year; no GRADE assessment was reported.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Caries lesion arrestment · Primary teeth with dentin caries lesions on occlusal and smooth surfaces
Silver diamine fluoride twice annually ranked first for caries lesion arrestment in the occlusal- and smooth-surface network (moderate certainty).
1 finding from 1 review
Specificity for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled specificity of radiographic detection for advanced occlusal caries was 91.4% (95% CI 88 to 94) (ungraded).
3 findings from 1 review
Specificity 91.4 [88, 94]
36 studies
GRADE not reported
Specificity 89.3 [86, 92]
44 studies
GRADE not reported
Specificity 89.1 [86, 92]
38 studies
GRADE not reported
Negative LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, the negative lr of visual detection for advanced occlusal caries was 0.58 (95% CI 0.5 to 0.7) (ungraded).
3 findings from 1 review
Negative LR 0.58 [0.5, 0.7]
50 studies
GRADE not reported
Negative LR 0.39 [0.3, 0.5]
94 studies
GRADE not reported
Negative LR 0.29 [0.2, 0.4]
55 studies
GRADE not reported
Specificity for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled specificity of radiographic detection for all (initial and advanced) occlusal caries was 84.8% (95% CI 77 to 90) (ungraded).
3 findings from 1 review
Specificity 84.8 [77, 90]
9 studies
GRADE not reported
Specificity 80.4 [72, 87]
11 studies
GRADE not reported
Specificity 77.8 [70, 84]
14 studies
GRADE not reported
Specificity for detecting all (initial and advanced) proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled specificity of radiographic detection for all (initial and advanced) proximal caries was 91.7% (95% CI 90 to 93) (ungraded).
3 findings from 1 review
Specificity 91.7 [90, 93]
34 studies
GRADE not reported
Specificity 90.0 [87, 92]
38 studies
GRADE not reported
Specificity 92.5 [91, 94]
31 studies
GRADE not reported
Positive LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, the positive lr of radiographic detection for advanced occlusal caries was 5.87 (95% CI 4.3 to 8.0) (ungraded).
3 findings from 1 review
Positive LR 5.87 [4.3, 8.0]
36 studies
GRADE not reported
Positive LR 4.9 [3.7, 6.5]
44 studies
GRADE not reported
Positive LR 5.96 [3.7, 6.6]
38 studies
GRADE not reported
Death · Patients with severe malaria
The fixed-effect NMR reported a difference between artesunate and quinine at every displayed average age; no GRADE assessment was reported.
2 findings from 1 review
no estimate extracted
Studies not reported
GRADE not reported
no estimate extracted
Studies not reported
GRADE not reported
Advanced occlusal carious lesions · Permanent molar surfaces in diagnostic accuracy studies (mostly in vitro; clinical)
Pooled specificity for visual detection of advanced occlusal lesions was 0.849 (95% CI 0.82 to 0.89).
2 findings from 1 review
Specificity 84.9 [82, 89]
55 studies
GRADE not reported
Specificity 90.9 [88, 93]
94 studies
GRADE not reported
Positive LR for detecting all (initial and advanced) proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the positive lr of radiographic detection for all (initial and advanced) proximal caries was 4.3 (95% CI 3.4 to 5.5) (ungraded).
3 findings from 1 review
Positive LR 4.3 [3.4, 5.5]
38 studies
GRADE not reported
Positive LR 4.89 [3.9, 6.2]
34 studies
GRADE not reported
Positive LR 5.34 [4.2, 6.8]
31 studies
GRADE not reported
NPV for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the Egyptian public health clinic setting, the negative predictive value of visual detection for all (initial and advanced) occlusal caries was 97.4% at an assumed prevalence of 12.9% (ungraded).
2 findings from 1 review
NPV 97.4
51 studies
GRADE not reported
NPV 68.6
12 studies
GRADE not reported
Treatment success rate · Primary teeth with dentin caries lesions on occlusoproximal surfaces
The Hall technique ranked first for treatment success in the occlusoproximal-surface network (low certainty).
1 finding from 1 review
Sensitivity for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, pooled sensitivity of radiographic detection for advanced occlusal caries was 54.2% (95% CI 47 to 61) (ungraded).
3 findings from 1 review
Sensitivity 54.2 [47, 61]
38 studies
GRADE not reported
Sensitivity 52.3 [44, 60]
44 studies
GRADE not reported
Sensitivity 50.8 [43, 59]
36 studies
GRADE not reported
Caries increment, surface index D(M)FS · Children or adolescents
The illustrative network meta-regression estimated an SMD for caries increment for fluoride in varnish versus fluoride in dentifrice across randomization year; the review did not state whether the difference was significant and certainty was not graded.
1 finding from 1 review